NPR1 |
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Identifiers |
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Aliases | NPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1 |
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External IDs | OMIM: 108960; MGI: 97371; HomoloGene: 37367; GeneCards: NPR1; OMA:NPR1 - orthologs |
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Gene location (Human) |
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![Chromosome 1 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 (human)[1] |
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| Band | 1q21.3 | Start | 153,678,688 bp[1] |
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End | 153,693,992 bp[1] |
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Gene location (Mouse) |
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![Chromosome 3 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png) | Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3 F1|3 39.23 cM | Start | 90,357,898 bp[2] |
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End | 90,373,173 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Descending thoracic aorta
- ascending aorta
- right uterine tube
- gastric mucosa
- left uterine tube
- right coronary artery
- left coronary artery
- subcutaneous adipose tissue
- right lung
- triceps brachii muscle
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| Top expressed in | - yolk sac
- spermatocyte
- muscle of thigh
- blastocyst
- morula
- adrenal gland
- lip
- esophagus
- thyroid gland
- dentate gyrus of hippocampal formation granule cell
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/6/6a/PBB_GE_NPR1_32625_at_fs.png/250px-PBB_GE_NPR1_32625_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/6/67/PBB_GE_NPR1_204648_at_fs.png/250px-PBB_GE_NPR1_204648_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein kinase activity
- nucleotide binding
- G protein-coupled peptide receptor activity
- hormone binding
- guanylate cyclase activity
- GTP binding
- lyase activity
- natriuretic peptide receptor activity
- phosphorus-oxygen lyase activity
- ATP binding
- peptide hormone binding
- adenylate cyclase activity
- protein kinase binding
- peptide receptor activity
| Cellular component | - integral component of membrane
- membrane
- plasma membrane
- receptor complex
- guanylate cyclase complex, soluble
- intracellular anatomical structure
| Biological process | - negative regulation of smooth muscle cell proliferation
- regulation of cardiac conduction
- intracellular signal transduction
- positive regulation of renal sodium excretion
- positive regulation of urine volume
- body fluid secretion
- cyclic nucleotide biosynthetic process
- receptor guanylyl cyclase signaling pathway
- regulation of blood pressure
- cGMP biosynthetic process
- protein phosphorylation
- cell surface receptor signaling pathway
- regulation of vascular permeability
- dopamine metabolic process
- negative regulation of cell growth
- negative regulation of angiogenesis
- G protein-coupled receptor signaling pathway
- blood vessel diameter maintenance
- positive regulation of cGMP-mediated signaling
- cGMP-mediated signaling
- signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 153.68 – 153.69 Mb | Chr 3: 90.36 – 90.37 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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