Nicotine polacrilex

Nicotine in ion-exchange resin

US DailyMed: Nicotine polacrilex

Routes of
administrationBy mouthATC code

None

UK: General sales list (GSL, OTC)^[1]^[2]
US: OTC^[3]

IdentifiersUNII

6M3C89ZY6R

Nicotine polacrilex is nicotine bound to an ion-exchange resin (polymethacrylic acid, such as Amberlite IRP64, Purolite C115HMR or Doshion P551).^[4] It is added to gum and hard lozenges used for nicotine replacement therapy in smoking cessation, such as in the Nicorette range of products. The use of the polymer as a delivery system maximizes the amount of nicotine released and absorbed by the oral mucosa. 80 to 90 percent of the nicotine released from the gum is absorbed by the mouth. Side effects of the gum include bad taste, nausea, dyspepsia, and stomatitis.

References

^ "Nicorette 2mg Gum Summary of Product Characteristics (SmPC)". emc. 1 September 2021. Retrieved 17 July 2024.
^ "Nicorette 4mg Gum Summary of Product Characteristics (SmPC)". emc. 1 September 2021. Retrieved 17 July 2024.
^ "Nicorette White Ice Mint- nicotine polacrilex gum, chewing Nicorette Original- nicotine polacrilex gum, chewing Nicorette Cinnamon Surge- nicotine polacrilex gum, chewing Nicorette Fresh Mint- nicotine polacrilex gum, chewing Nicorette Mint- nicotine polacrilex gum, chewing Nicorette Spearmint Burst- nicotine polacrilex gum, chewing". DailyMed. Retrieved 11 November 2021.
^ "Nicotine polacrilex". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2021-11-12. Retrieved 2021-11-12.