Nuala Helsby

Professor of pathology in New Zealand

Inter-individual Variation in the Metabolism and Pharmacokinetics of the Antimalarial Biguanides

Academic workInstitutionsUniversity of Auckland

Nuala Ann Helsby FBPhS is a New Zealand academic, and is a full professor of molecular medicine and pathology at the University of Auckland, specialising in transport of anticancer pharmaceuticals and drug treatments for autoimmune conditions.

Academic career

Helsby completed a PhD titled Inter-individual Variation in the Metabolism and Pharmacokinetics of the Antimalarial Biguanides at the University of Liverpool.^[1]^[2] Helsby carried out postdoctoral research at Liverpool and the University of Birmingham, before joining the faculty of the University of Auckland. She initially worked in the Auckland Cancer Society Research Centre, before taking up a position in the Department of Molecular Medicine and Pathology. She was appointed full professor in 2024.^[3]^[4]^[5]

Helsby was an executive editor of the British Journal of Clinical Pharmacology for seven years.^[2] Helsby is Vice-chair of the Drug Metabolism and Transporter Section of the International Union of Basic and Clinical Pharmacology, and is the New Zealand representative on the board of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists.^[2]

Helsby's research focuses on transport of anti-cancer drugs and treatments for autoimmune conditions, and genetic variations in drug metabolism.^[3]^[2] She is part of a team, led by Rhys Ponton, investigating the link between fast metabolism of codeine and propensity for addiction.^[6] She has also written about the importance of assessing drug metabolism individually rather than relying on ethnic background as a predictor.^[7]

Selected works

Scholia has a profile for Nuala Helsby (Q42421366).

Stephen P H Alexander; Doriano Fabbro; Eamonn Kelly; et al. (16 September 2021). "THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes". British Journal of Pharmacology. 178 (S1). doi:10.1111/BPH.15542. ISSN 0007-1188. Wikidata Q119459640.
Ward SA; Helsby NA; Skjelbo E; Brøsen K; Gram LF; Breckenridge AM (1 June 1991). "The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study". British Journal of Clinical Pharmacology. 31 (6): 689–692. doi:10.1111/J.1365-2125.1991.TB05594.X. ISSN 0306-5251. PMC 1368581. PMID 1867963. Wikidata Q34358893.
G Edwards; A Dingsdale; Nuala Helsby; M L Orme; A M Breckenridge (1 January 1988). "The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution". European Journal of Clinical Pharmacology. 35 (6): 681–684. doi:10.1007/BF00637608. ISSN 0031-6970. PMID 3234475. Wikidata Q52460898.
Nuala Helsby; Ferry DM; Adam Patterson; Pullen SM; Wilson WR (1 March 2004). "2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT". British Journal of Cancer. 90 (5): 1084–1092. doi:10.1038/SJ.BJC.6601612. ISSN 0007-0920. PMC 2409616. PMID 14997211. Wikidata Q38797133.
William R Wilson; Susan M Pullen; Alison Hogg; Nuala Helsby; Kevin O Hicks; William A Denny (1 March 2002). "Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures". Cancer Research. 62 (5): 1425–1432. ISSN 0008-5472. PMID 11888915. Wikidata Q43913566.
Helsby NA; Ward SA; Edwards G; Howells RE; Breckenridge AM (1 October 1990). "The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism". British Journal of Clinical Pharmacology. 30 (4): 593–598. doi:10.1111/J.1365-2125.1990.TB03818.X. ISSN 0306-5251. PMC 1368250. PMID 2291871. Wikidata Q39063279.
Hui-Ming Lin; Matthew P G Barnett; Nicole C Roy; et al. (1 April 2010). "Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease". Journal of Proteome Research. 9 (4): 1965–1975. doi:10.1021/PR901130S. ISSN 1535-3893. PMID 20141220. Wikidata Q43169057.

References

^ Helsby, Nuala Ann (1991). Inter-individual Variation in the Metabolism and Pharmacokinetics of the Antimalarial Biguanides (PhD thesis). University of Liverpool.
^ ^a ^b ^c ^d "Profile | British Pharmacological Society". www.bps.ac.uk. Retrieved 9 May 2024.
^ ^a ^b "Our Medical Committee | Auckland Medical Research Foundation". AMRF. Retrieved 9 May 2024.
^ "2024 Calendar: PDF Version - The University of Auckland". www.calendar.auckland.ac.nz. Retrieved 9 May 2024.
^ University of Auckland. "Academic profile: Professor Nuala Helsby".
^ Wall, Tony (4 September 2022). "World-first study by Auckland scientists hopes to show genetic link to codeine addiction". www.stuff.co.nz. Retrieved 9 May 2024.
^ "DNA databases are too white, so genetics doesn't help everyone. How do we fix that?". 4 March 2021. Retrieved 9 May 2024.