OR5AR1

Protein-coding gene in the species Homo sapiens
OR5AR1
Identifiers
AliasesOR5AR1, OR11-209, olfactory receptor family 5 subfamily AR member 1 (gene/pseudogene), olfactory receptor family 5 subfamily AR member 1
External IDsMGI: 3030853; HomoloGene: 17464; GeneCards: OR5AR1; OMA:OR5AR1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR5AR1
Genomic location for OR5AR1
Band11q12.1Start56,663,686 bp[1]
End56,664,618 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OR5AR1
Genomic location for OR5AR1
Band2|2 DStart85,669,965 bp[2]
End85,675,827 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • multicellular organism
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • olfactory receptor activity
  • odorant binding
  • copper ion binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • response to stimulus
  • signal transduction
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
  • detection of chemical stimulus involved in sensory perception
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

219493

259017

Ensembl

ENSG00000172459

ENSMUSG00000075208

UniProt

Q8NGP9

Q8VGS3

RefSeq (mRNA)

NM_001004730

NM_147015

RefSeq (protein)

NP_001004730

NP_667226

Location (UCSC)Chr 11: 56.66 – 56.66 MbChr 2: 85.67 – 85.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 5AR1 is a protein that in humans is encoded by the OR5AR1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172459 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075208 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR5AR1 olfactory receptor, family 5, subfamily AR, member 1".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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