OXSR1

Protein-coding gene in the species Homo sapiens
OXSR1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2V3S, 2VWI, 3DAK

Identifiers
AliasesOXSR1, OSR1, oxidative stress responsive 1, oxidative stress responsive kinase 1
External IDsOMIM: 604046; MGI: 1917378; HomoloGene: 31288; GeneCards: OXSR1; OMA:OXSR1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for OXSR1
Genomic location for OXSR1
Band3p22.2Start38,165,089 bp[1]
End38,255,484 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for OXSR1
Genomic location for OXSR1
Band9|9 F3Start119,067,498 bp[2]
End119,151,493 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • Skeletal muscle tissue of rectus abdominis

  • mucosa of pharynx

  • body of tongue

  • saphenous vein

  • gastrocnemius muscle

  • embryo

  • ganglionic eminence

  • glutes

  • ventricular zone
Top expressed in
  • muscle of thigh

  • skeletal muscle tissue

  • genital tubercle

  • quadriceps femoris muscle

  • cumulus cell

  • tail of embryo

  • knee joint

  • triceps brachii muscle

  • ankle

  • medullary collecting duct
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • magnesium ion binding
  • protein kinase activity
  • protein binding
  • kinase activity
  • metal ion binding
  • nucleotide binding
  • transferase activity
  • ATP binding
  • protein serine/threonine kinase activity
  • identical protein binding
  • protein kinase binding
Cellular component
  • extracellular exosome
  • cytoplasm
  • cytosol
Biological process
  • response to oxidative stress
  • negative regulation of potassium ion transmembrane transport
  • cellular hypotonic response
  • phosphorylation
  • negative regulation of potassium ion transmembrane transporter activity
  • protein phosphorylation
  • peptidyl-threonine phosphorylation
  • intracellular signal transduction
  • regulation of mitotic cell cycle
  • signal transduction
  • stress-activated protein kinase signaling cascade
  • activation of protein kinase activity
  • regulation of apoptotic process
  • osmosensory signaling pathway
  • positive regulation of T cell chemotaxis
  • chemokine (C-C motif) ligand 21 signaling pathway
  • chemokine (C-X-C motif) ligand 12 signaling pathway
  • protein autophosphorylation
  • cellular response to chemokine
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9943

108737

Ensembl

ENSG00000172939

ENSMUSG00000036737

UniProt

O95747

Q6P9R2

RefSeq (mRNA)

NM_005109

NM_133985
NM_001359582

RefSeq (protein)

NP_005100

NP_598746
NP_001346511

Location (UCSC)Chr 3: 38.17 – 38.26 MbChr 9: 119.07 – 119.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.[5][6]

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172939 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036737 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tamari M, Daigo Y, Nakamura Y (Apr 1999). "Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3". J Hum Genet. 44 (2): 116–20. doi:10.1007/s100380050121. PMID 10083736.
  6. ^ a b "Entrez Gene: OXSR1 oxidative-stress responsive 1".

Further reading

  • Daigo Y, Isomura M, Nishiwaki T, et al. (1999). "Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3". DNA Res. 6 (1): 37–44. doi:10.1093/dnares/6.1.37. PMID 10231028.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Piechotta K, Lu J, Delpire E (2003). "Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)". J. Biol. Chem. 277 (52): 50812–9. doi:10.1074/jbc.M208108200. PMID 12386165.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chen W, Yazicioglu M, Cobb MH (2004). "Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily". J. Biol. Chem. 279 (12): 11129–36. doi:10.1074/jbc.M313562200. PMID 14707132.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Moriguchi T, Urushiyama S, Hisamoto N, et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". J. Biol. Chem. 280 (52): 42685–93. doi:10.1074/jbc.M510042200. PMID 16263722.
  • Cusick JK, Xu LG, Bin LH, et al. (2006). "Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1". Biochem. Biophys. Res. Commun. 340 (2): 535–43. doi:10.1016/j.bbrc.2005.12.033. PMID 16389068.
  • Vitari AC, Thastrup J, Rafiqi FH, et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMC 1479760. PMID 16669787.
  • Anselmo AN, Earnest S, Chen W, et al. (2006). "WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells". Proc. Natl. Acad. Sci. U.S.A. 103 (29): 10883–8. Bibcode:2006PNAS..10310883A. doi:10.1073/pnas.0604607103. PMC 1544143. PMID 16832045.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Villa F, Goebel J, Rafiqi FH, et al. (2007). "Structural insights into the recognition of substrates and activators by the OSR1 kinase". EMBO Rep. 8 (9): 839–45. doi:10.1038/sj.embor.7401048. PMC 1973955. PMID 17721439.


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