olfactory marker protein |
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Identifiers |
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Symbol | OMP |
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NCBI gene | 4975 |
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HGNC | 8136 |
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OMIM | 164340 |
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RefSeq | NM_006189 |
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UniProt | P47874 |
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Other data |
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Locus | Chr. 11 q14-q21 |
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Search for |
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Structures | Swiss-model |
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Domains | InterPro |
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Olfactory marker protein |
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solution structure of olfactory marker protein from rat |
Identifiers |
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Symbol | Olfactory_mark |
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Pfam | PF06554 |
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InterPro | IPR009103 |
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SCOP2 | 1jyt / SCOPe / SUPFAM |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.[1] Three highly conserved regions have been identified as possible protein–protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.[2]
External links
References
- ^ Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL (June 2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37. doi:10.1016/S0022-2836(02)00282-6. PMID 12054873.
- ^ Smith PC, Firestein S, Hunt JF (June 2002). "The crystal structure of the olfactory marker protein at 2.3 A resolution". J. Mol. Biol. 319 (3): 807–21. doi:10.1016/S0022-2836(02)00242-5. PMID 12054872.
This article incorporates text from the public domain
Pfam and
InterPro: IPR009103
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