PAFAH1B2

Protein-coding gene in the species Homo sapiens

PAFAH1B2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1VYH

Identifiers
AliasesPAFAH1B2, HEL-S-303, platelet activating factor acetylhydrolase 1b catalytic subunit 2
External IDsOMIM: 602508; MGI: 108415; HomoloGene: 1932; GeneCards: PAFAH1B2; OMA:PAFAH1B2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PAFAH1B2
Genomic location for PAFAH1B2
Band11q23.3Start117,144,284 bp[1]
End117,176,894 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for PAFAH1B2
Genomic location for PAFAH1B2
Band9|9 A5.2Start45,962,859 bp[2]
End46,012,690 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • pons

  • inferior ganglion of vagus nerve

  • superior vestibular nucleus

  • trigeminal ganglion

  • pars reticulata

  • subthalamic nucleus

  • Pars compacta

  • middle temporal gyrus

  • lateral nuclear group of thalamus
Top expressed in
  • spermatid

  • spermatocyte

  • tail of embryo

  • renal corpuscle

  • genital tubercle

  • mandibular prominence

  • neural tube

  • central gray substance of midbrain

  • somite

  • maxillary prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • 1-alkyl-2-acetylglycerophosphocholine esterase activity
  • platelet-activating factor acetyltransferase activity
  • hydrolase activity
  • protein homodimerization activity
  • protein heterodimerization activity
  • phospholipase A2 activity
  • protein binding
Cellular component
  • plasma membrane
  • nucleolus
  • extracellular exosome
  • fibrillar center
  • extracellular region
  • cytoplasm
  • cytosol
  • secretory granule lumen
  • ficolin-1-rich granule lumen
Biological process
  • lipid catabolic process
  • positive regulation of macroautophagy
  • brain development
  • spermatogenesis
  • lipid metabolism
  • neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5049

18475

Ensembl

ENSG00000168092

ENSMUSG00000003131

UniProt

P68402

Q61206

RefSeq (mRNA)

NM_001184746
NM_001184747
NM_001184748
NM_001309431
NM_002572

NM_008775

RefSeq (protein)

NP_001171675
NP_001171676
NP_001171677
NP_001296360
NP_002563

NP_032801
NP_001344167
NP_001344168
NP_001344169
NP_001344170

NP_001344172
NP_001344173
NP_001344174
NP_001344175

Location (UCSC)Chr 11: 117.14 – 117.18 MbChr 9: 45.96 – 46.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.[5][6][7]

Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168092 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003131 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Apr 1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I)". Biochemical and Biophysical Research Communications. 233 (1): 10–3. doi:10.1006/bbrc.1997.6383. PMID 9144386.
  6. ^ Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics. 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
  7. ^ "Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa".
  8. ^ Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.

Further reading

  • Albrecht U, Abu-Issa R, Rätz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G (Dec 1996). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor". Developmental Biology. 180 (2): 579–93. doi:10.1006/dbio.1996.0330. PMID 8954729.
  • Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
  • Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering. 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
  • Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
  • Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Hasstedt SJ, Scott BT, Rosendaal FR, Callas PW, Vossen CY, Long GL, Bovill EG (Sep 2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample". Thrombosis and Haemostasis. 98 (3): 587–92. doi:10.1160/th07-02-0134. PMID 17849047. S2CID 7180897.
  • v
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  • 1fxw: CRYSTAL STRUCTURE OF THE RECOMBINANT ALPHA1/ALPHA2 CATALYTIC HETERODIMER OF BOVINE BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB.
    1fxw: CRYSTAL STRUCTURE OF THE RECOMBINANT ALPHA1/ALPHA2 CATALYTIC HETERODIMER OF BOVINE BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB.
  • 1vyh: PAF-AH HOLOENZYME: LIS1/ALFA2
    1vyh: PAF-AH HOLOENZYME: LIS1/ALFA2
  • v
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PAF receptor modulators
PAFRTooltip Platelet-activating factor receptor
Agonists
Antagonists
Others
Precursors
See also
Receptor/signaling modulators


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