PAPLN

Protein-coding gene in the species Homo sapiens
PAPLN
Identifiers
AliasesPAPLN, papilin, proteoglycan like sulfated glycoprotein, PPN
External IDsOMIM: 617785; MGI: 2386139; HomoloGene: 71541; GeneCards: PAPLN; OMA:PAPLN - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for PAPLN
Genomic location for PAPLN
Band14q24.2Start73,237,497 bp[1]
End73,274,640 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for PAPLN
Genomic location for PAPLN
Band12|12 D1Start83,810,408 bp[2]
End83,839,156 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibial nerve

  • tendon of biceps brachii

  • decidua

  • trigeminal ganglion

  • spinal ganglia

  • gastric mucosa

  • sural nerve

  • skin of arm

  • left uterine tube

  • lymph node
Top expressed in
  • molar

  • lip

  • spermatocyte

  • esophagus

  • superior frontal gyrus

  • yolk sac

  • neural layer of retina

  • muscle of thigh

  • primary visual cortex

  • spermatid
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase inhibitor activity
  • peptidase activity
  • serine-type endopeptidase inhibitor activity
Cellular component
  • extracellular region
Biological process
  • negative regulation of peptidase activity
  • negative regulation of endopeptidase activity
  • proteolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89932

170721

Ensembl

ENSG00000100767

ENSMUSG00000021223

UniProt

O95428

Q9EPX2

RefSeq (mRNA)

NM_173462
NM_001365906
NM_001365907

NM_001205343
NM_130887

RefSeq (protein)

NP_775733
NP_001352835
NP_001352836

NP_001192272
NP_570957

Location (UCSC)Chr 14: 73.24 – 73.27 MbChr 12: 83.81 – 83.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Papilin is a protein that in humans is encoded by the PAPLN gene.[5][6][7] Papilin is an extracellular matrix glycoprotein.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100767 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021223 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: papilin".
  6. ^ Kramerova IA, Kawaguchi N, Fessler LI, Nelson RE, Chen Y, Kramerov AA, Kusche-Gullberg M, Kramer JM, Ackley BD, Sieron AL, Prockop DJ, Fessler JH (December 2000). "Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases". Development. 127 (24): 5475–85. doi:10.1242/dev.127.24.5475. PMID 11076767.
  7. ^ Apte SS (November 2009). "A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms". J. Biol. Chem. 284 (46): 31493–7. doi:10.1074/jbc.R109.052340. PMC 2797218. PMID 19734141.

Further reading

  • Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Laje G, Allen AS, Akula N, et al. (2009). "Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients". Pharmacogenet. Genomics. 19 (9): 666–74. doi:10.1097/FPC.0b013e32832e4bcd. PMC 2819190. PMID 19724244.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.