PCDH20

Protein-coding gene in the species Homo sapiens
PCDH20
Identifiers
AliasesPCDH20, PCDH13, protocadherin 20
External IDsOMIM: 614449; MGI: 2443376; HomoloGene: 11277; GeneCards: PCDH20; OMA:PCDH20 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for PCDH20
Genomic location for PCDH20
Band13q21.2Start61,409,685 bp[1]
End61,415,522 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for PCDH20
Genomic location for PCDH20
Band14|14 E1Start88,702,179 bp[2]
End88,708,832 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • superior frontal gyrus

  • testicle

  • prefrontal cortex

  • hippocampus proper

  • popliteal artery

  • tibial arteries

  • Achilles tendon

  • Brodmann area 9

  • anterior cingulate cortex

  • Descending thoracic aorta
Top expressed in
  • utricle

  • vestibular sensory epithelium

  • vestibular membrane of cochlear duct

  • dentate gyrus

  • dentate gyrus of hippocampal formation granule cell

  • hippocampus proper

  • lumbar subsegment of spinal cord

  • endolymphatic duct

  • Region I of hippocampus proper

  • mammillary body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • RNA binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • cell adhesion
  • homophilic cell adhesion via plasma membrane adhesion molecules
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64881

219257

Ensembl

ENSG00000280165

ENSMUSG00000050505

UniProt

Q8N6Y1

Q8BIZ0

RefSeq (mRNA)

NM_022843

NM_178685

RefSeq (protein)

NP_073754

NP_848800

Location (UCSC)Chr 13: 61.41 – 61.42 MbChr 14: 88.7 – 88.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protocadherin-20 is a protein that in humans is encoded by the PCDH20 gene.[5]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000280165 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050505 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PCDH20 protocadherin 20".

Further reading

  • Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
  • Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
  • Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
  • Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.


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