PCDH7

Protein-coding gene in the species Homo sapiens
PCDH7
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2YST

Identifiers
AliasesPCDH7, BH-Pcdh, BHPCDH, PPP1R120, protocadherin 7
External IDsOMIM: 602988; MGI: 1860487; HomoloGene: 36101; GeneCards: PCDH7; OMA:PCDH7 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for PCDH7
Genomic location for PCDH7
Band4p15.1Start30,720,369 bp[1]
End31,146,805 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for PCDH7
Genomic location for PCDH7
Band5|5 C1Start57,875,309 bp[2]
End58,290,572 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • middle temporal gyrus

  • Brodmann area 23

  • urethra

  • saphenous vein

  • corpus epididymis

  • seminal vesicula

  • pons

  • entorhinal cortex

  • postcentral gyrus
Top expressed in
  • ascending aorta

  • arcuate nucleus

  • anterior amygdaloid area

  • ventromedial nucleus

  • subiculum

  • median eminence

  • paraventricular nucleus of hypothalamus

  • lateral geniculate nucleus

  • aortic valve

  • medial geniculate nucleus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
  • platelet alpha granule membrane
Biological process
  • cell adhesion
  • homophilic cell adhesion via plasma membrane adhesion molecules
  • platelet degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5099

54216

Ensembl

ENSG00000169851

ENSMUSG00000029108

UniProt

O60245

n/a

RefSeq (mRNA)

NM_001173523
NM_002589
NM_032456
NM_032457

NM_001122758
NM_018764
NM_001310606
NM_001310608

RefSeq (protein)

NP_001166994
NP_002580
NP_115832
NP_115833

n/a

Location (UCSC)Chr 4: 30.72 – 31.15 MbChr 5: 57.88 – 58.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.[5][6]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell–cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169851 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029108 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics. 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID 9615233.
  6. ^ a b "Entrez Gene: PCDH7 protocadherin 7".

Further reading

  • Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
  • Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
  • Yoshida K, Watanabe M, Kato H, et al. (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain". FEBS Lett. 460 (1): 93–8. doi:10.1016/S0014-5793(99)01309-5. PMID 10571067. S2CID 24377126.
  • Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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