PLA2G4C

PLA2G4C
Identifiers
Aliases	PLA2G4C, CPLA2-gamma, phospholipase A2 group IVC
External IDs	OMIM: 603602; MGI: 1196403; HomoloGene: 115256; GeneCards: PLA2G4C; OMA:PLA2G4C - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,047,843 bp[1] End 48,110,817 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 7.84 cM Start 13,058,580 bp[2] End 13,094,597 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes inferior ganglion of vagus nerve muscle of thigh C1 segment vastus lateralis muscle corpus callosum right hemisphere of cerebellum apex of heart Skeletal muscle tissue of rectus abdominis triceps brachii muscle Top expressed in zygote secondary oocyte primary oocyte epithelium of stomach lumbar spinal ganglion Paneth cell morula parotid gland tail of embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase activity calcium-independent phospholipase A2 activity phospholipid binding hydrolase activity phospholipase A2 activity phospholipase A1 activity lysophospholipase activity calcium ion binding calcium-dependent phospholipid binding calcium-dependent phospholipase A2 activity Cellular component cytosol endoplasmic reticulum membrane membrane nuclear envelope nucleoplasm cell cortex cytoplasm Biological process intracellular signal transduction phosphatidylethanolamine acyl-chain remodeling glycerophospholipid catabolic process lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process birth phospholipid catabolic process phospholipid metabolic process metabolism inflammatory response arachidonic acid metabolic process phosphatidylcholine acyl-chain remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8605 232889 Ensembl ENSG00000105499 ENSMUSG00000033847 UniProt Q9UP65 Q64GA5 RefSeq (mRNA) NM_001159322 NM_001159323 NM_003706 NM_001004762 NM_001168504 RefSeq (protein) NP_001152794 NP_001152795 NP_003697 NP_003697.2 NP_001004762 NP_001161976 Location (UCSC) Chr 19: 48.05 – 48.11 Mb Chr 7: 13.06 – 13.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene.^[5][6]

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• Jenkins CM, Han X, Yang J, Mancuso DJ, Sims HF, Muslin AJ, Gross RW (2004). "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis". Biochemistry. 42 (40): 11798–807. doi:10.1021/bi034611q. PMID 14529291.
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• Yan W, Jenkins CM, Han X, Mancuso DJ, Sims HF, Yang K, Gross RW (2005). "The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling". J. Biol. Chem. 280 (29): 26669–79. doi:10.1074/jbc.M502358200. PMID 15908428.
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