PNPLA8 |
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Identifiers |
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Aliases | PNPLA8, IPLA2(GAMMA), IPLA2-2, IPLA2G, iPLA2gamma, MMLA, PNPLA-gamma, patatin like phospholipase domain containing 8 |
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External IDs | OMIM: 612123; MGI: 1914702; HomoloGene: 12136; GeneCards: PNPLA8; OMA:PNPLA8 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 7 (human)[1] |
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| Band | 7q31.1 | Start | 108,470,417 bp[1] |
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End | 108,569,666 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 12 (mouse)[2] |
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| Band | 12|12 B2 | Start | 44,268,153 bp[2] |
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End | 44,369,315 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - endothelial cell
- pancreatic epithelial cell
- tibialis anterior muscle
- deltoid muscle
- entorhinal cortex
- myocardium of left ventricle
- Pars compacta
- right ventricle
- pars reticulata
- corpus callosum
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| Top expressed in | - muscle of thigh
- brown adipose tissue
- intercostal muscle
- vastus lateralis muscle
- temporal muscle
- myocardium of ventricle
- sternocleidomastoid muscle
- triceps brachii muscle
- mammary gland
- soleus muscle
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - lysophospholipase activity
- calcium-independent phospholipase A2 activity
- hydrolase activity
- ATP binding
- phospholipase A2 activity
| Cellular component | - cytoplasm
- integral component of membrane
- Golgi apparatus
- endoplasmic reticulum membrane
- membrane
- Golgi membrane
- peroxisomal membrane
- peroxisome
- intracellular anatomical structure
- endoplasmic reticulum
- perinuclear region of cytoplasm
| Biological process | - linoleic acid metabolic process
- phosphatidylethanolamine acyl-chain remodeling
- phosphatidylcholine catabolic process
- lipid metabolism
- cell death
- fatty acid metabolic process
- lipid catabolic process
- phosphatidylethanolamine catabolic process
- prostaglandin biosynthetic process
- metabolism
- arachidonic acid metabolic process
- phosphatidylcholine acyl-chain remodeling
- arachidonic acid secretion
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001256007 NM_001256008 NM_001256009 NM_001256010 NM_001256011
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NM_015723 |
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RefSeq (protein) | NP_001242936 NP_001242937 NP_001242938 NP_001242939 NP_001242940
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NP_056538 |
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Location (UCSC) | Chr 7: 108.47 – 108.57 Mb | Chr 12: 44.27 – 44.37 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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