POLR2G

Protein-coding gene in the species Homo sapiens

POLR2G

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2C35, 5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6

Identifiers

Aliases

POLR2G, RPB19, RPB7, hRPB19, hsRPB7, polymerase (RNA) II subunit G, RNA polymerase II subunit G

External IDs

OMIM: 602013; MGI: 1914960; HomoloGene: 2019; GeneCards: POLR2G; OMA:POLR2G - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q12.3	Start	62,761,565 bp^[1]
Band	11q12.3	End	62,766,710 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	8,770,491 bp^[2]
Band	19\|19 A	End	8,775,941 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

granulocyte

ganglionic eminence

C1 segment

right adrenal gland

right adrenal cortex

monocyte

stromal cell of endometrium

Descending thoracic aorta

rectum

Top expressed in

medial ganglionic eminence

endocardial cushion

primary oocyte

facial motor nucleus

otic placode

atrioventricular junction

condyle

primitive streak

renal corpuscle

mandibular prominence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity single-stranded DNA binding single-stranded RNA binding RNA binding nucleic acid binding translation initiation factor binding
Cellular component	P-body nucleoplasm RNA polymerase II, core complex nucleus
Biological process	mRNA splicing, via spliceosome positive regulation of nuclear-transcribed mRNA poly(A) tail shortening transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter positive regulation of translational initiation nuclear-transcribed mRNA catabolic process, exonucleolytic apoptotic process snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5436


67710

Ensembl


ENSG00000168002


ENSMUSG00000071662

UniProt


P62487


P62488

RefSeq (mRNA)


NM_002696


NM_026329

RefSeq (protein)


NP_002687


NP_080605

Location (UCSC)

Chr 11: 62.76 – 62.77 Mb

Chr 19: 8.77 – 8.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.^[5]^[6]

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.^[7]

Interactions

POLR2G has been shown to interact with TAF15,^[8] POLR2C,^[9] POLR2H^[9] and POLR2E.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168002 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071662 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Khazak V, Sadhale PP, Woychik NA, Brent R, Golemis EA (December 1995). "Human RNA polymerase II subunit hsRPB7 functions in yeast and influences stress survival and cell morphology". Mol Biol Cell. 6 (7): 759–75. doi:10.1091/mbc.6.7.759. PMC 301239. PMID 7579693.
^ Schoen TJ, Chandrasekharappa SC, Guru SC, Mazuruk K, Chader GJ, Rodriguez IR (August 1997). "Human gene for the RNA polymerase II seventh subunit (hsRPB7): structure, expression and chromosomal localization". Biochim Biophys Acta. 1353 (1): 39–49. doi:10.1016/s0167-4781(97)00041-9. PMID 9256063.
^ "Entrez Gene: POLR2G polymerase (RNA) II (DNA directed) polypeptide G".
^ Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (March 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. 18 (3). UNITED STATES: 1489–97. doi:10.1128/mcb.18.3.1489. ISSN 0270-7306. PMC 108863. PMID 9488465.
^ ^a ^b ^c Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27). UNITED STATES: 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

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