POLR2J

Protein-coding gene in the species Homo sapiens

POLR2J

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6

Identifiers

Aliases

POLR2J, POLR2J1, RPB11, RPB11A, RPB11m, hRPB14, polymerase (RNA) II subunit J, RNA polymerase II subunit J

External IDs

OMIM: 604150; MGI: 109582; HomoloGene: 4542; GeneCards: POLR2J; OMA:POLR2J - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q22.1	Start	102,473,128 bp^[1]
Band	7q22.1	End	102,478,922 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 G2	Start	136,145,485 bp^[2]
Band	5\|5 G2	End	136,151,801 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

muscle of thigh

apex of heart

left ventricle

right auricle

left adrenal cortex

mucosa of transverse colon

substantia nigra

putamen

amygdala

Top expressed in

yolk sac

zygote

embryo

morula

embryo

otic placode

internal carotid artery

ventricular zone

primary oocyte

epiblast

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding LRR domain binding protein dimerization activity DNA-directed 5'-3' RNA polymerase activity protein binding RNA polymerase II activity
Cellular component	nucleoplasm nucleus RNA polymerase II, core complex
Biological process	mRNA splicing, via spliceosome transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway RNA metabolic process regulation of gene silencing by miRNA transcription by RNA polymerase II transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5439


20022

Ensembl


ENSG00000005075


ENSMUSG00000039771

UniProt


P52435


O08740

RefSeq (mRNA)


NM_006234 NM_001371100 NM_001393919


NM_011293

RefSeq (protein)


NP_006225 NP_001358029


n/a

Location (UCSC)

Chr 7: 102.47 – 102.48 Mb

Chr 5: 136.15 – 136.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene.

Function

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13.^[5]

Interactions

POLR2J has been shown to interact with:

Apoptosis antagonizing transcription factor,^[6]
POLR2C,^[7]^[8] and
SATB1.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005075 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039771 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa".
^ Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J. 14 (7): 904–12. doi:10.1096/fasebj.14.7.904. PMID 10783144. S2CID 43175069.
^ Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. PMID 9201987.
^ Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, Floridi A, Fanciulli M, Passananti C (October 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB J. 16 (12): 1639–41. doi:10.1096/fj.02-0123fje. PMID 12207009. S2CID 30243193.
^ Durrin LK, Krontiris TG (June 2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics. 79 (6): 809–17. doi:10.1006/geno.2002.6772. PMID 12036295.

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