POLR2L

Protein-coding gene in the species Homo sapiens

POLR2L
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5FLM, 5IYD, 5IYC, 5IY8, 5IYA, 5IYB, 5IY6, 5IY9, 5IY7

Identifiers
AliasesPOLR2L, RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6, polymerase (RNA) II subunit L, RNA polymerase II subunit L, RNA polymerase II, I and III subunit L
External IDsOMIM: 601189; MGI: 1913741; HomoloGene: 129854; GeneCards: POLR2L; OMA:POLR2L - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for POLR2L
Genomic location for POLR2L
Band11p15.5Start837,356 bp[1]
End842,529 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for POLR2L
Genomic location for POLR2L
Band7|7 F5Start141,051,773 bp[2]
End141,055,045 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • right ventricle

  • left ventricle

  • right auricle

  • myocardium of left ventricle

  • abdominal fat

  • mucosa of transverse colon

  • biceps brachii

  • right adrenal gland

  • body of pancreas
Top expressed in
  • morula

  • embryo

  • proximal tubule

  • embryo

  • adrenal gland

  • right kidney

  • lens

  • bone marrow

  • yolk sac

  • muscle of thigh
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • zinc ion binding
  • RNA polymerase II activity
  • metal ion binding
  • RNA polymerase III activity
  • DNA-directed 5'-3' RNA polymerase activity
  • protein binding
  • RNA polymerase I activity
Cellular component
  • cytosol
  • nucleoplasm
  • RNA polymerase I complex
  • RNA polymerase III complex
  • RNA polymerase II, core complex
  • nucleus
Biological process
  • termination of RNA polymerase I transcription
  • mRNA splicing, via spliceosome
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • regulation of transcription by RNA polymerase I
  • transcription initiation from RNA polymerase I promoter
  • transcription elongation from RNA polymerase II promoter
  • 7-methylguanosine mRNA capping
  • transcription by RNA polymerase II
  • transcription-coupled nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • fibroblast growth factor receptor signaling pathway
  • transcription by RNA polymerase III
  • snRNA transcription by RNA polymerase II
  • RNA metabolic process
  • regulation of gene silencing by miRNA
  • transcription, DNA-templated
  • transcription elongation from RNA polymerase I promoter
  • positive regulation of type I interferon production
  • somatic stem cell population maintenance
  • positive regulation of viral transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5441

66491

Ensembl

ENSG00000177700

ENSMUSG00000038489

UniProt

P62875

P62876

RefSeq (mRNA)

NM_021128

NM_025593

RefSeq (protein)

NP_066951

NP_079869

Location (UCSC)Chr 11: 0.84 – 0.84 MbChr 7: 141.05 – 141.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene.[5]

Function

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.[6]

Interactions

POLR2L has been shown to interact with POLR2C,[7] POLR2A,[7] POLR2B[7] and POLR2E.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177700 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038489 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (September 1996). "The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase". Genomics. 32 (1): 86–90. doi:10.1006/geno.1996.0079. PMID 8786124.
  6. ^ "Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa".
  7. ^ a b c d Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. PMID 9201987.

Further reading

  • Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
  • Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. Bibcode:1998CBio....8.R447Y. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
  • Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359. S2CID 43685090.
  • Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi:10.1080/152165401753544241. PMID 11547919. S2CID 10931640.
  • Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMC 7168390. PMID 16838299.
  • Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
  • Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
  • Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID 2190099. S2CID 4233742.
  • Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
  • Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M (1995). "Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae". Mol. Cell. Biol. 15 (9): 4702–10. doi:10.1128/mcb.15.9.4702. PMC 230713. PMID 7651387.
  • Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–20. doi:10.1128/JVI.69.3.1612-1620.1995. PMC 188757. PMID 7853496.
  • McKune K, Moore PA, Hull MW, Woychik NA (1996). "Six human RNA polymerase subunits functionally substitute for their yeast counterparts". Mol. Cell. Biol. 15 (12): 6895–900. doi:10.1128/mcb.15.12.6895. PMC 230944. PMID 8524256.
  • Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. doi:10.1073/pnas.93.6.2505. PMC 39827. PMID 8637904.
  • Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–84. doi:10.1128/JVI.70.7.4576-4584.1996. PMC 190394. PMID 8676484.
  • Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID 8800208.
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
  • Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. doi:10.1073/pnas.93.21.11575. PMC 38099. PMID 8876177.
  • Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". J. Biol. Chem. 271 (44): 27888–94. doi:10.1074/jbc.271.44.27888. PMID 8910388.


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