POPDC3

Protein-coding gene in the species Homo sapiens
POPDC3
Identifiers
AliasesPOPDC3, POP3, bA355M14.1, popeye domain containing 3, LGMDR26
External IDsOMIM: 605824; MGI: 1930153; HomoloGene: 32540; GeneCards: POPDC3; OMA:POPDC3 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for POPDC3
Genomic location for POPDC3
Band6q21Start105,157,900 bp[1]
End105,180,014 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for POPDC3
Genomic location for POPDC3
Band10 B2|10 23.35 cMStart45,054,194 bp[2]
End45,194,548 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Skeletal muscle tissue of rectus abdominis

  • biceps brachii

  • muscle of thigh

  • vastus lateralis muscle

  • thoracic diaphragm

  • gastrocnemius muscle

  • Skeletal muscle tissue of biceps brachii

  • glutes

  • deltoid muscle

  • triceps brachii muscle
Top expressed in
  • triceps brachii muscle

  • temporal muscle

  • vastus lateralis muscle

  • sternocleidomastoid muscle

  • gastrocnemius muscle

  • digastric muscle

  • ankle

  • medial head of gastrocnemius muscle

  • soleus muscle

  • lumbar spinal ganglion
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cAMP binding
  • nucleotide binding
  • molecular function
Cellular component
  • membrane
  • integral component of membrane
  • sarcolemma
Biological process
  • biological process
  • regulation of membrane potential
  • heart development
  • skeletal muscle tissue development
  • striated muscle cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64208

78977

Ensembl

ENSG00000132429

ENSMUSG00000019848

UniProt

Q9HBV1

Q9ES81

RefSeq (mRNA)

NM_022361

NM_024286

RefSeq (protein)

NP_071756

NP_077248

Location (UCSC)Chr 6: 105.16 – 105.18 MbChr 10: 45.05 – 45.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Popeye domain-containing protein 3 is a protein that in humans is encoded by the POPDC3 gene.[5][6]

Function

This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132429 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019848 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: popeye domain containing 3".
  6. ^ Andrée B, Hillemann T, Kessler-Icekson G, Schmitt-John T, Jockusch H, Arnold HH, Brand T (July 2000). "Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart". Dev. Biol. 223 (2): 371–82. doi:10.1006/dbio.2000.9751. PMID 10882522.

Further reading

  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  • Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951. S2CID 3005450.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sulem P, Gudbjartsson DF, Rafnar T, et al. (2009). "Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche". Nat. Genet. 41 (6): 734–8. doi:10.1038/ng.383. PMID 19448622. S2CID 7425600.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.


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