PPADS
Names | |
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IUPAC name 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzene-1,3-disulfonic acid | |
Other names PPADS | |
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Properties | |
Chemical formula | C14H14N3O12PS2 |
Molar mass | 511.37 g·mol−1 |
Appearance | Orange solid |
Solubility in water | 100 mM (tetrasodium salt)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) is a selective purinergic P2X antagonist.[2] It is able to block contractions of rabbit vas deferens induced by ATP or α,β,methylene-ATP. It appears to be relatively selective for P2X receptors, having no appreciable activity at α1 adrenergic, muscarinic M2 and M3, histamine H1, and adenosine A1 receptors.[3]
References
- ^ PPADS tetrasodium salt, Santa Cruz Biotechnology
- ^ Ziganshin, AU (December 1993). "PPADS selectively antagonizes P2X-purinoceptor-mediated responses in the rabbit urinary bladder". British Journal of Pharmacology. 110 (4): 1491–95. doi:10.1111/j.1476-5381.1993.tb13990.x. PMC 2175839. PMID 8306091.
- ^ Lambrecht, G. (1992). "PPADS, a novel functionally selective antagonist of P2 purinoreceptor mediated responses". European Journal of Pharmacology. 217 (2–3): 217–19. doi:10.1016/0014-2999(92)90877-7. PMID 1330591.
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Purine receptor modulators
(ligands)
P0 (adenine) |
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P1 (adenosine) |
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P2 (nucleotide) |
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(blockers)
CNTsTooltip Concentrative nucleoside transporters |
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ENTsTooltip Equilibrative nucleoside transporters | |
PMATTooltip Plasma membrane monoamine transporter |
(inhibitors)
XOTooltip Xanthine oxidase | |
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Others |
See also: Receptor/signaling modulators
This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it. |
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