PPP3R1

Protein-coding gene in the species Homo sapiens

PPP3R1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1AUI, 1M63, 1MF8, 2P6B, 3LL8, 4F0Z, 4OR9, 4ORA, 4ORC, 4ORB

Identifiers
AliasesPPP3R1, CALNB1, CNB, CNB1, protein phosphatase 3 regulatory subunit B, alpha
External IDsOMIM: 601302; MGI: 107172; HomoloGene: 68099; GeneCards: PPP3R1; OMA:PPP3R1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PPP3R1
Genomic location for PPP3R1
Band2p14Start68,178,857 bp[1]
End68,256,237 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for PPP3R1
Genomic location for PPP3R1
Band11|11 A2Start17,109,263 bp[2]
End17,150,375 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 9

  • nucleus accumbens

  • Achilles tendon

  • right frontal lobe

  • monocyte

  • caudate nucleus

  • prefrontal cortex

  • putamen

  • cerebellar hemisphere

  • amygdala
Top expressed in
  • CA3 field

  • perirhinal cortex

  • Region I of hippocampus proper

  • olfactory tubercle

  • entorhinal cortex

  • dentate gyrus

  • prefrontal cortex

  • primary motor cortex

  • primary visual cortex

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium ion binding
  • protein domain specific binding
  • metal ion binding
  • calmodulin binding
  • protein binding
  • calcium-dependent protein serine/threonine phosphatase activity
  • cyclosporin A binding
  • phosphoprotein phosphatase activity
  • phosphatase binding
Cellular component
  • cytoplasm
  • cytosol
  • membrane
  • plasma membrane
  • nucleoplasm
  • sarcolemma
  • calcineurin complex
  • mitochondrion
Biological process
  • Fc-epsilon receptor signaling pathway
  • positive regulation of transcription by RNA polymerase II
  • protein dephosphorylation
  • Wnt signaling pathway, calcium modulating pathway
  • branching involved in blood vessel morphogenesis
  • epithelial to mesenchymal transition
  • heart development
  • Schwann cell development
  • myelination in peripheral nervous system
  • calcineurin-NFAT signaling cascade
  • protein localization to nucleus
  • lung epithelial cell differentiation
  • protein import into nucleus
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5534

19058

Ensembl

ENSG00000221823

ENSMUSG00000033953

UniProt

P63098

Q63810

RefSeq (mRNA)

NM_000945

NM_024459

RefSeq (protein)

NP_000936

NP_077779

Location (UCSC)Chr 2: 68.18 – 68.26 MbChr 11: 17.11 – 17.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.[5][6][7]

Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000221823 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033953 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID 8978785.
  6. ^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.
  7. ^ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform".
  8. ^ Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ (ed.). "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLOS Genet. 6 (9): e1001101. doi:10.1371/journal.pgen.1001101. PMC 2940763. PMID 20862329.

Further reading

  • Kawamura A, Su MS (1995). "Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain". J. Biol. Chem. 270 (26): 15463–6. doi:10.1074/jbc.270.26.15463. PMID 7541044.
  • Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0. PMID 8524402. S2CID 4337105.
  • Feng B, Stemmer PM (1999). "Interactions of calcineurin A, calcineurin B, and Ca2+". Biochemistry. 38 (38): 12481–9. doi:10.1021/bi990492w. PMID 10493818.
  • Stratakis CA, Taymans SE (1999). "Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15)". DNA Seq. 9 (4): 227–30. doi:10.3109/10425179809105209. PMID 10520753.
  • Nishio H, Matsui K, Tsuji H, et al. (2000). "Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis". Histochem. Cell Biol. 114 (1): 9–14. doi:10.1007/s004180000168. PMID 10959817. S2CID 21530150.
  • Sokal I, Li N, Verlinde CL, et al. (2001). "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1)". Biochim. Biophys. Acta. 1498 (2–3): 233–51. doi:10.1016/S0167-4889(00)00099-9. PMID 11108966.
  • Graef IA, Chen F, Chen L, et al. (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183. S2CID 5278706.
  • Al-Daraji WI, Grant KR, Ryan K, et al. (2002). "Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A." J. Invest. Dermatol. 118 (5): 779–88. doi:10.1046/j.1523-1747.2002.01709.x. PMID 11982754.
  • Huai Q, Kim HY, Liu Y, et al. (2002). "Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12037–42. Bibcode:2002PNAS...9912037H. doi:10.1073/pnas.192206699. PMC 129394. PMID 12218175.
  • Jin L, Harrison SC (2002). "Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13522–6. Bibcode:2002PNAS...9913522J. doi:10.1073/pnas.212504399. PMC 129706. PMID 12357034.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Bittinger MA, McWhinnie E, Meltzer J, et al. (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Curr. Biol. 14 (23): 2156–61. doi:10.1016/j.cub.2004.11.002. PMID 15589160. S2CID 5934014.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Winslow MM, Gallo EM, Neilson JR, Crabtree GR (2006). "The calcineurin phosphatase complex modulates immunogenic B cell responses". Immunity. 24 (2): 141–52. doi:10.1016/j.immuni.2005.12.013. PMID 16473827.
  • Liu Q, Wilkins BJ, Lee YJ, et al. (2006). "Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth". Mol. Cell. Biol. 26 (10): 3785–97. doi:10.1128/MCB.26.10.3785-3797.2006. PMC 1489013. PMID 16648474.
  • v
  • t
  • e
  • 1aui: HUMAN CALCINEURIN HETERODIMER
    1aui: HUMAN CALCINEURIN HETERODIMER
  • 1m63: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
    1m63: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
  • 1mf8: Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
    1mf8: Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
  • 1tco: TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
    1tco: TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
  • 2p6b: Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide
    2p6b: Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide


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