PRKCB |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/31/Protein_PRKCB1_PDB_1a25.png/250px-Protein_PRKCB1_PDB_1a25.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | PRKCB, PKC-beta, PKCB, PRKCB1, PRKCB2, protein kinase C beta, PKCbeta, PKCI(2) |
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External IDs | OMIM: 176970; MGI: 97596; HomoloGene: 56424; GeneCards: PRKCB; OMA:PRKCB - orthologs |
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Gene location (Human) |
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![Chromosome 16 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/2/2d/Ideogram_human_chromosome_16.svg/300px-Ideogram_human_chromosome_16.svg.png) | Chr. | Chromosome 16 (human)[1] |
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| Band | 16p12.2-p12.1 | Start | 23,835,983 bp[1] |
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End | 24,220,611 bp[1] |
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Gene location (Mouse) |
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![Chromosome 7 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7 F2|7 65.75 cM | Start | 121,887,974 bp[2] |
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End | 122,233,625 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - middle temporal gyrus
- orbitofrontal cortex
- frontal pole
- Brodmann area 23
- Brodmann area 46
- superior frontal gyrus
- Brodmann area 10
- parietal lobe
- Region I of hippocampus proper
- postcentral gyrus
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| Top expressed in | - dorsal striatum
- olfactory tubercle
- primary motor cortex
- perirhinal cortex
- Region I of hippocampus proper
- cingulate gyrus
- CA3 field
- superior frontal gyrus
- visual cortex
- prefrontal cortex
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - transferase activity
- nucleotide binding
- protein kinase activity
- protein kinase C activity
- histone binding
- zinc ion binding
- calcium channel regulator activity
- chromatin binding
- metal ion binding
- kinase activity
- protein serine/threonine kinase activity
- protein binding
- androgen receptor binding
- nuclear receptor coactivator activity
- histone kinase activity (H3-T6 specific)
- ATP binding
- protein kinase C binding
- calcium-dependent protein kinase C activity
| Cellular component | - cytoplasm
- membrane
- plasma membrane
- extracellular exosome
- nucleus
- nucleoplasm
- cytosol
- calyx of Held
- presynaptic cytosol
| Biological process | - B cell receptor signaling pathway
- cellular response to carbohydrate stimulus
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- positive regulation of B cell receptor signaling pathway
- intracellular signal transduction
- response to hypoxia
- regulation of transcription, DNA-templated
- adaptive immune response
- phosphorylation
- immune system process
- regulation of transcription by RNA polymerase II
- cellular calcium ion homeostasis
- transcription, DNA-templated
- positive regulation of angiogenesis
- platelet activation
- protein phosphorylation
- B cell activation
- negative regulation of insulin receptor signaling pathway
- mitotic nuclear membrane disassembly
- negative regulation of glucose transmembrane transport
- positive regulation of NF-kappaB transcription factor activity
- peptidyl-serine phosphorylation
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- calcium ion transport
- signal transduction
- lipoprotein transport
- apoptotic process
- regulation of myeloid cell differentiation
- chromatin organization
- presynaptic modulation of chemical synaptic transmission
- positive regulation of nucleic acid-templated transcription
- regulation of synaptic vesicle exocytosis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 16: 23.84 – 24.22 Mb | Chr 7: 121.89 – 122.23 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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