PRKRIR

Protein-coding gene in the species Homo sapiens
THAP12
Identifiers
AliasesTHAP12, DAP4, P52rIPK, THAP0, PRKRIR, THAP domain containing 12
External IDsOMIM: 607374; MGI: 1920231; HomoloGene: 37952; GeneCards: THAP12; OMA:THAP12 - orthologs
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[1]
Chromosome 7 (mouse)
Genomic location for THAP12
Genomic location for THAP12
Band7|7 E1Start98,352,310 bp[1]
End98,367,269 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • corpus epididymis

  • trabecular bone

  • caput epididymis

  • retinal pigment epithelium

  • secondary oocyte

  • ganglionic eminence

  • body of pancreas

  • lactiferous duct

  • superficial temporal artery
Top expressed in
  • triceps brachii muscle

  • temporal muscle

  • sternocleidomastoid muscle

  • vastus lateralis muscle

  • gastrocnemius muscle

  • muscle of thigh

  • digastric muscle

  • medial head of gastrocnemius muscle

  • intercostal muscle

  • ankle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • nucleic acid binding
  • protein dimerization activity
  • protein binding
  • DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • cytoplasm
Biological process
  • negative regulation of cell population proliferation
  • signal transduction
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5612

72981

Ensembl

n/a

ENSMUSG00000030753

UniProt

O43422

Q9CUX1

RefSeq (mRNA)

NM_004705

NM_028410
NM_001355114

RefSeq (protein)

NP_004696

NP_082686
NP_001342043

Location (UCSC)n/aChr 7: 98.35 – 98.37 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

52 kDa repressor of the inhibitor of the protein kinase is an enzyme that in humans is encoded by the PRKRIR gene.[4][5]

Interactions

PRKRIR has been shown to interact with STK4[6] and DNAJC3.[4]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030753 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b Gale M Jr; Blakely CM; Hopkins DA; Melville MW; Wambach M; Romano PR; Katze MG (Feb 1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK". Mol Cell Biol. 18 (2): 859–71. doi:10.1128/mcb.18.2.859. PMC 108797. PMID 9447982.
  5. ^ "Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)".
  6. ^ Lin, Yenshou; Khokhlatchev Andrei; Figeys Daniel; Avruch Joseph (Dec 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50). United States: 47991–8001. doi:10.1074/jbc.M202630200. ISSN 0021-9258. PMID 12384512.

Further reading

  • Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochem. Biophys. Res. Commun. 178 (2): 430–7. doi:10.1016/0006-291X(91)90125-Q. PMID 1677563.
  • Polyak SJ, Tang N, Wambach M, et al. (1996). "The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity". J. Biol. Chem. 271 (3): 1702–7. doi:10.1074/jbc.271.3.1702. PMID 8576172.
  • Shi Y, Vattem KM, Sood R, et al. (1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control". Mol. Cell. Biol. 18 (12): 7499–509. doi:10.1128/MCB.18.12.7499. PMC 109330. PMID 9819435.
  • Lu J, O'Hara EB, Trieselmann BA, et al. (1999). "The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha". J. Biol. Chem. 274 (45): 32198–203. doi:10.1074/jbc.274.45.32198. PMID 10542257.
  • Saelens X, Kalai M, Vandenabeele P (2001). "Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation". J. Biol. Chem. 276 (45): 41620–8. doi:10.1074/jbc.M103674200. PMID 11555640.
  • Lin Y, Khokhlatchev A, Figeys D, Avruch J (2003). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. PMID 12384512.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lee JH, Choi SR, Hwang TH, et al. (2004). "A gene expression in study human gastric adenocarcinoma using a cDNA microarray". The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi. 42 (6): 484–95. PMID 14695705.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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