Protein-coding gene in the species Homo sapiens
PURG |
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Identifiers |
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Aliases | PURG, PURG-A, PURG-B, purine-rich element binding protein G, purine rich element binding protein G, PURGA, PURGB |
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External IDs | OMIM: 618041; MGI: 1922279; HomoloGene: 22747; GeneCards: PURG; OMA:PURG - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 8 (human)[1] |
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| Band | 8p12 | Start | 30,995,802 bp[1] |
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End | 31,033,715 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 8 (mouse)[2] |
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| Band | 8|8 A3 | Start | 33,876,353 bp[2] |
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End | 33,907,495 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sperm
- middle temporal gyrus
- Brodmann area 23
- endothelial cell
- cerebellar vermis
- entorhinal cortex
- postcentral gyrus
- internal globus pallidus
- superior frontal gyrus
- primary visual cortex
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| Top expressed in | - barrel cortex
- substantia nigra
- superior cervical ganglion
- Region I of hippocampus proper
- trigeminal ganglion
- fossa
- condyle
- motor neuron
- medial geniculate nucleus
- medial dorsal nucleus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA binding
- RNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- double-stranded DNA binding
- purine-rich negative regulatory element binding
- sequence-specific DNA binding
| Cellular component | | Biological process | - negative regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001015508 NM_013357 NM_001323311 NM_001323312 |
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NM_001098233 NM_152821 NM_001382855 |
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RefSeq (protein) | |
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NP_001015508 NP_001310240 NP_001310241 NP_037489 |
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NP_001091703 NP_690034 NP_001369784 |
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Location (UCSC) | Chr 8: 31 – 31.03 Mb | Chr 8: 33.88 – 33.91 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Purine-rich element binding protein G is a protein that in humans is encoded by the PURG gene.[5]
Function
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A (PURA). The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. Two transcript variants encoding different isoforms have been found for this gene.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000172733 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049184 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Purine-rich element binding protein G". Retrieved 2015-12-27.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.