Protein-coding gene in the species Homo sapiens
THEMIS |
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Identifiers |
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Aliases | THEMIS, C6orf190, C6orf207, GASP, SPOT, TSEPA, bA325O24.3, bA325O24.4, thymocyte selection associated |
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External IDs | OMIM: 613607; MGI: 2443552; HomoloGene: 72287; GeneCards: THEMIS; OMA:THEMIS - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 6 (human)[1] |
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| Band | 6q22.33 | Start | 127,708,072 bp[1] |
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End | 127,918,631 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10|10 A4 | Start | 28,544,356 bp[2] |
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End | 28,759,814 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - lymph node
- granulocyte
- testicle
- appendix
- blood
- primary visual cortex
- epithelium of colon
- superior frontal gyrus
- prefrontal cortex
- tonsil
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| Top expressed in | - thymus
- blood
- lymph node
- mesenteric lymph nodes
- oocyte
- subcutaneous adipose tissue
- primary oocyte
- secondary oocyte
- spleen
- zygote
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - cytoplasm
- COP9 signalosome
- nucleus
- cell-cell junction
| Biological process | - multicellular organism development
- T cell receptor signaling pathway
- adaptive immune response
- negative T cell selection
- positive T cell selection
- immune system process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000275122 ENSG00000172673 |
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UniProt | | |
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RefSeq (mRNA) | NM_001010923 NM_001164685 NM_001164687 NM_001318531 NM_001394520
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NM_001394521 NM_001394522 |
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NM_178666 NM_001305663 NM_001374699 |
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RefSeq (protein) | |
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NP_001010923 NP_001158157 NP_001158159 NP_001305460 |
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NP_001292592 NP_848781 NP_001361628 |
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Location (UCSC) | Chr 6: 127.71 – 127.92 Mb | Chr 10: 28.54 – 28.76 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Protein THEMIS is a protein encoded by the eponymous THEMIS gene.[5][6][7]
Function
This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[8] Changes in THEMIS gene expression due to the rs138300818 variant promote the development of early-onset type 1 diabetes.[9]
Etimology
THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.[10]
References
- ^ a b c ENSG00000172673 GRCh38: Ensembl release 89: ENSG00000275122, ENSG00000172673 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049109 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, et al. (August 2009). "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nature Immunology. 10 (8): 848–856. doi:10.1038/ni.1766. PMC 2757056. PMID 19597499.
- ^ Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, et al. (August 2009). "Themis, a T cell-specific protein important for late thymocyte development". Nature Immunology. 10 (8): 840–847. doi:10.1038/ni.1768. PMC 2848698. PMID 19597498.
- ^ Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, et al. (August 2009). "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nature Immunology. 10 (8): 831–839. doi:10.1038/ni.1769. PMC 2908989. PMID 19597497.
- ^ "Entrez Gene: thymocyte selection associated".
- ^ Sandholm N, Rubio García A, Pekalski ML, Inshaw JR, Cutler AJ, Todd JA (August 2022). "Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants". Scientific Reports. 12 (1): 14137. Bibcode:2022NatSR..1214137S. doi:10.1038/s41598-022-18296-4. PMC 9391468. PMID 35986039.
- ^ Zielinska E (2009-11-01). "Six degrees of science". The Scientist. Archived from the original on 2009-11-06. Retrieved 2009-11-03.
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, et al. (May 2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nature Biotechnology. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
- Allen PM (August 2009). "Themis imposes new law and order on positive selection". Nature Immunology. 10 (8): 805–806. doi:10.1038/ni0809-805. PMID 19621038. S2CID 205359914.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.