RALGDS
Protein-coding gene in the species Homo sapiens
RALGDS | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | RALGDS, RGDS, RGF, RalGEF, ral guanine nucleotide dissociation stimulator | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601619; MGI: 107485; HomoloGene: 4562; GeneCards: RALGDS; OMA:RALGDS - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans.[5][6]
Interactions
RALGDS has been shown to interact with:
- Arrestin beta 1,[7]
- Arrestin beta 2,[7]
- HRAS,[5][8][9][10][11][12][13][14]
- KRAS,[8][10]
- MRAS,[15][16]
- RAP1A,[9][17]
- RAP2A,[17]
- RAPGEF2,[8] and
- RRAS.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000160271 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026821 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Hofer F, Fields S, Schneider C, Martin GS (December 1994). "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator". Proc Natl Acad Sci U S A. 91 (23): 11089–93. Bibcode:1994PNAS...9111089H. doi:10.1073/pnas.91.23.11089. PMC 45172. PMID 7972015.
- ^ "Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator".
- ^ a b Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nat. Cell Biol. 4 (8): 547–55. doi:10.1038/ncb821. PMID 12105416. S2CID 20784208.
- ^ a b c d Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
- ^ a b Boettner B, Govek EE, Cross J, Van Aelst L (August 2000). "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064–9. Bibcode:2000PNAS...97.9064B. doi:10.1073/pnas.97.16.9064. PMC 16822. PMID 10922060.
- ^ a b Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. doi:10.1101/gad.14.8.895. PMC 316541. PMID 10783161.
- ^ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
- ^ Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (February 1997). "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. doi:10.1074/jbc.272.9.5600. PMID 9038168.
- ^ Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (May 1997). "Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras". Cell. 89 (3): 457–67. doi:10.1016/s0092-8674(00)80226-3. PMID 9150145. S2CID 14459536.
- ^ Stang S, Bottorff D, Stone JC (June 1997). "Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells". Mol. Cell. Biol. 17 (6): 3047–55. doi:10.1128/MCB.17.6.3047. PMC 232157. PMID 9154803.
- ^ Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (November 1997). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.
- ^ Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (October 1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616. S2CID 40024826.
- ^ a b Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (March 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
Further reading
- Spaargaren M, Bischoff JR (1995). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
- Albright CF, Giddings BW, Liu J, Vito M, Weinberg RA (1993). "Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase". EMBO J. 12 (1): 339–47. doi:10.1002/j.1460-2075.1993.tb05662.x. PMC 413211. PMID 8094051.
- Urano T, Emkey R, Feig LA (1996). "Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation". EMBO J. 15 (4): 810–6. doi:10.1002/j.1460-2075.1996.tb00416.x. PMC 450279. PMID 8631302.
- Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (1997). "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. doi:10.1074/jbc.272.9.5600. PMID 9038168.
- Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795. PMID 9155018.
- Geyer M, Herrmann C, Wohlgemuth S, Wittinghofer A, Kalbitzer HR (1997). "Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling". Nat. Struct. Biol. 4 (9): 694–9. doi:10.1038/nsb0997-694. hdl:11858/00-001M-0000-0024-AF7E-E. PMID 9302994. S2CID 3189922.
- Humphrey D, Kwiatkowska J, Henske EP, Haines JL, Halley D, van Slegtenhorst M, Kwiatkowski DJ (1997). "Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1". Ann. Hum. Genet. 61 (Pt 4): 299–305. doi:10.1046/j.1469-1809.1997.6140299.x. PMID 9365783. S2CID 20453717.
- Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (1998). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.
- Shirouzu M, Morinaka K, Koyama S, Hu CD, Hori-Tamura N, Okada T, Kariya K, Kataoka T, Kikuchi A, Yokoyama S (1998). "Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS". J. Biol. Chem. 273 (13): 7737–42. doi:10.1074/jbc.273.13.7737. PMID 9516482.
- Okada S, Matsuda M, Anafi M, Pawson T, Pessin JE (1998). "Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes". EMBO J. 17 (9): 2554–65. doi:10.1093/emboj/17.9.2554. PMC 1170597. PMID 9564038.
- Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
- Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616. S2CID 40024826.
- Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
- Zheng Q, Yu L, Zhao Y, Sun X, Dai F, Hu P, Fu Q, Geng Z (2000). "[Refined chromosome assignment of human novel H-RalGDS gene on chromosome 9q34.1 by using radiation hybrid genebridge 4 panel]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 17 (1): 1–5. PMID 10653898.
- Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
- Zheng Q, Yu L, Zhao Y, Zhang H, Fu Q, Mao N, Hu P, Geng Z, Zhao S (2001). "Structure characterization of human RalGDS gene, and the identification of its novel variant". Mol. Biol. Rep. 27 (4): 209–16. doi:10.1023/A:1011043122220. PMID 11455956. S2CID 7866224.
- Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A, Kelley GG, Der CJ (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587.
- Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K". Oncogene. 21 (6): 937–46. doi:10.1038/sj.onc.1205144. PMID 11840339. S2CID 20848629.
- Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA (2002). "PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism". EMBO J. 21 (6): 1327–38. doi:10.1093/emboj/21.6.1327. PMC 125928. PMID 11889038.
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PDB gallery
- 1lfd: CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS
- 1lxd: CRYSTAL STRUCTURE OF THE RAS INTERACTING DOMAIN OF RALGDS, A GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR OF RAL PROTEIN
- 1rax: RA-DOMAIN OF RAL GUANOSINE-NUCLEOTIDE DISSOCIATION STIMULATOR
- 2b3a: Solution structure of the Ras-binding domain of the Ral Guanosine Dissociation Stimulator
- 2rgf: RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES