RAP1GDS1

Protein-coding gene in the species Homo sapiens

RAP1GDS1
Identifiers
AliasesRAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDsOMIM: 179502; MGI: 2385189; HomoloGene: 41422; GeneCards: RAP1GDS1; OMA:RAP1GDS1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for RAP1GDS1
Genomic location for RAP1GDS1
Band4q23Start98,261,384 bp[1]
End98,443,861 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for RAP1GDS1
Genomic location for RAP1GDS1
Band3|3 H1Start138,631,663 bp[2]
End138,780,962 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • pons

  • Pars compacta

  • trigeminal ganglion

  • pars reticulata

  • middle temporal gyrus

  • spinal ganglia

  • superior vestibular nucleus

  • sperm

  • corpus callosum
Top expressed in
  • medial dorsal nucleus

  • medial geniculate nucleus

  • lateral geniculate nucleus

  • perirhinal cortex

  • inferior colliculus

  • olfactory epithelium

  • visual cortex

  • pontine nuclei

  • primary motor cortex

  • CA3 field
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • GTPase activator activity
Cellular component
  • cytosol
  • extracellular exosome
  • endoplasmic reticulum
  • mitochondrion
Biological process
  • negative regulation of endoplasmic reticulum calcium ion concentration
  • positive regulation of mitochondrial calcium ion concentration
  • vascular associated smooth muscle contraction
  • myosin filament assembly
  • small GTPase mediated signal transduction
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5910

229877

Ensembl

ENSG00000138698

ENSMUSG00000028149

UniProt

P52306

E9Q912

RefSeq (mRNA)
NM_001100426
NM_001100427
NM_001100428
NM_001100429
NM_001100430

NM_021159

NM_001040690
NM_001286759
NM_145544
NM_001356388

RefSeq (protein)
NP_001093896
NP_001093897
NP_001093898
NP_001093899
NP_001093900

NP_066982

NP_001035780
NP_001273688
NP_001343317
NP_663519

Location (UCSC)Chr 4: 98.26 – 98.44 MbChr 3: 138.63 – 138.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.[5][6][7]


Interactions

RAP1GDS1 has been shown to interact with KIFAP3,[8] HRAS[9] and RHOA.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138698 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028149 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526. S2CID 21189125.
  6. ^ Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.
  7. ^ "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
  8. ^ Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.
  9. ^ a b Vikis HG, Stewart Scott, Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427. S2CID 6647800.

Further reading

  • Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21". Oncogene. 7 (2): 289–93. PMID 1549351.
  • Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189.
  • Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. PMID 11948427. S2CID 6647800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes". J. Biol. Chem. 278 (25): 22412–7. doi:10.1074/jbc.M212036200. PMID 12690117.
  • Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis". Blood. 103 (7): 2661–7. doi:10.1182/blood-2003-06-2154. PMID 14615375.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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