RBPJ |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Protein_RBPJ_PDB_2f8x.png/250px-Protein_RBPJ_PDB_2f8x.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2F8X, 3NBN, 3V79 |
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Identifiers |
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Aliases | RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1 |
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External IDs | OMIM: 147183; MGI: 96522; HomoloGene: 7511; GeneCards: RBPJ; OMA:RBPJ - orthologs |
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Gene location (Human) |
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![Chromosome 4 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_human_chromosome_4.svg/300px-Ideogram_human_chromosome_4.svg.png) | Chr. | Chromosome 4 (human)[1] |
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| Band | 4p15.2 | Start | 26,163,455 bp[1] |
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End | 26,435,131 bp[1] |
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Gene location (Mouse) |
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![Chromosome 5 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png) | Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5 C1|5 29.37 cM | Start | 53,623,494 bp[2] |
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End | 53,814,704 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - inferior olivary nucleus
- Achilles tendon
- nipple
- corpus callosum
- dorsal motor nucleus of vagus nerve
- middle temporal gyrus
- synovial joint
- inferior ganglion of vagus nerve
- pericardium
- visceral pleura
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| Top expressed in | - vestibular membrane of cochlear duct
- stroma of bone marrow
- ventricular zone
- zygote
- renal corpuscle
- carotid body
- ciliary body
- Paneth cell
- medial ganglionic eminence
- ankle
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/d/da/PBB_GE_RBPJ_211974_x_at_fs.png/250px-PBB_GE_RBPJ_211974_x_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - protein N-terminus binding
- protein binding
- DNA strand exchange activity
- chromatin binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA binding
- transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
- DNA-binding transcription factor activity
- sequence-specific DNA binding
- transcription factor binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Cellular component | - nucleolus
- MAML1-RBP-Jkappa- ICN1 complex
- transcription regulator complex
- cytoplasm
- nucleus
- nucleoplasm
- transcription repressor complex
| Biological process | - artery morphogenesis
- regulation of transcription by RNA polymerase II
- neuron differentiation
- epidermal cell fate specification
- positive regulation of cell population proliferation
- club cell differentiation
- somatic stem cell population maintenance
- endocardium development
- cell fate commitment
- DNA recombination
- somitogenesis
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
- defense response to bacterium
- regulation of timing of cell differentiation
- regulation of transcription, DNA-templated
- humoral immune response
- keratinocyte differentiation
- hair follicle maturation
- negative regulation of cell population proliferation
- pituitary gland development
- negative regulation of cell differentiation
- Notch signaling involved in heart development
- transcription, DNA-templated
- positive regulation of gene expression
- arterial endothelial cell fate commitment
- myeloid dendritic cell differentiation
- blood vessel remodeling
- secondary heart field specification
- regulation of cell population proliferation
- positive regulation of transcription by RNA polymerase II
- transcription initiation from RNA polymerase II promoter
- sebaceous gland development
- positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
- inflammatory response to antigenic stimulus
- heart development
- auditory receptor cell fate commitment
- B cell differentiation
- regulation of gene expression
- Notch signaling pathway
- dorsal aorta morphogenesis
- atrioventricular canal development
- positive regulation of ephrin receptor signaling pathway
- epithelial to mesenchymal transition involved in endocardial cushion formation
- outflow tract morphogenesis
- cardiac left ventricle morphogenesis
- negative regulation of transcription by RNA polymerase II
- labyrinthine layer blood vessel development
- blood vessel lumenization
- endocardium morphogenesis
- ventricular trabecula myocardium morphogenesis
- negative regulation of ossification
- positive regulation of cell proliferation involved in heart morphogenesis
- positive regulation of cardiac muscle cell proliferation
- angiogenesis
- epithelial to mesenchymal transition
- positive regulation of BMP signaling pathway
- positive regulation of ERBB signaling pathway
- blood vessel endothelial cell fate specification
- negative regulation of transcription, DNA-templated
- positive regulation of transcription of Notch receptor target
- positive regulation of Notch signaling pathway
- hemopoiesis
- aortic valve development
- pulmonary valve development
- ventricular septum morphogenesis
- negative regulation of cold-induced thermogenesis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_005349 NM_015874 NM_203283 NM_203284 NM_001363577
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NM_001374400 NM_001374401 NM_001374402 NM_001374403 NM_001379406 NM_001379407 NM_001379408 NM_001379409 |
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NM_001080927 NM_001080928 NM_001277116 NM_009035 NM_001359152 |
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RefSeq (protein) | NP_005340 NP_056958 NP_976028 NP_976029 NP_001350506
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NP_001361329 NP_001361330 NP_001361331 NP_001361332 NP_001366335 NP_001366336 NP_001366337 NP_001366338 |
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NP_001074396 NP_001074397 NP_001264045 NP_033061 NP_001346081 |
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Location (UCSC) | Chr 4: 26.16 – 26.44 Mb | Chr 5: 53.62 – 53.81 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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