RGS11

Protein-coding gene in the species Homo sapiens
RGS11
Identifiers
AliasesRGS11, RS11, regulator of G-protein signaling 11, regulator of G protein signaling 11
External IDsOMIM: 603895; MGI: 1354739; HomoloGene: 77719; GeneCards: RGS11; OMA:RGS11 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for RGS11
Genomic location for RGS11
Band16p13.3Start268,301 bp[1]
End275,980 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for RGS11
Genomic location for RGS11
Band17|17 A3.3Start26,421,925 bp[2]
End26,430,298 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • anterior pituitary

  • C1 segment

  • cingulate gyrus

  • anterior cingulate cortex

  • tibial nerve

  • amygdala

  • Brodmann area 9

  • apex of heart
Top expressed in
  • neural layer of retina

  • superior frontal gyrus

  • morula

  • primary visual cortex

  • islet of Langerhans

  • adrenal gland

  • ganglion of vagus nerve

  • autonomic nerve plexus

  • CA3 field

  • stomach
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • G-protein beta-subunit binding
  • GTPase activator activity
  • GTPase activity
Cellular component
  • cytoplasm
  • plasma membrane
  • protein-containing complex
  • intracellular anatomical structure
Biological process
  • G protein-coupled receptor signaling pathway
  • negative regulation of signal transduction
  • intracellular signal transduction
  • regulation of G protein-coupled receptor signaling pathway
  • positive regulation of GTPase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8786

50782

Ensembl

ENSG00000076344

ENSMUSG00000024186

UniProt

O94810

Q9Z2H1

RefSeq (mRNA)

NM_001286485
NM_001286486
NM_003834
NM_183337

NM_001081069

RefSeq (protein)

NP_001273414
NP_001273415
NP_003825
NP_899180

NP_001074538

Location (UCSC)Chr 16: 0.27 – 0.28 MbChr 17: 26.42 – 26.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.[5][6]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076344 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024186 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
  6. ^ a b "Entrez Gene: RGS11 regulator of G-protein signalling 11".

Further reading

  • Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" (PDF). Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553. S2CID 4362044.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. S2CID 16065132.
  • Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
  • Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
  • Gold SJ, Ni YG, Dohlman HG, Nestler EJ (1997). "Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain". J. Neurosci. 17 (20): 8024–37. doi:10.1523/JNEUROSCI.17-20-08024.1997. PMC 6793903. PMID 9315921.


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