RNA polymerase II subunit B4

Protein-coding gene in the species Homo sapiens

POLR2D

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2C35, 5IYD, 5IY8, 5IYC, 5IY6, 5IY7, 5IYA, 5IY9, 5IYB

Identifiers

Aliases

POLR2D, HSRBP4, HSRPB4, RBP4, RPB16, RNA polymerase II subunit B4, polymerase (RNA) II subunit D, RNA polymerase II subunit D, RPB4

External IDs

OMIM: 606017; MGI: 1916491; HomoloGene: 37968; GeneCards: POLR2D; OMA:POLR2D - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q14.3	Start	127,843,553 bp^[1]
Band	2q14.3	End	127,858,155 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 B1	Start	31,922,212 bp^[2]
Band	18\|18 B1	End	31,929,754 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

left testis

right testis

pancreatic ductal cell

tibialis anterior muscle

ganglionic eminence

ventricular zone

islet of Langerhans

gastrocnemius muscle

quadriceps femoris muscle

Top expressed in

primary oocyte

yolk sac

ventricular zone

embryo

embryo

secondary oocyte

epiblast

endocardial cushion

medial ganglionic eminence

morula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding DNA-directed 5'-3' RNA polymerase activity single-stranded DNA binding catalytic activity single-stranded RNA binding translation initiation factor binding
Cellular component	P-body RNA polymerase II, core complex nucleus nucleoplasm cytosol nuclear speck nuclear DNA-directed RNA polymerase complex RNA polymerase complex
Biological process	mRNA splicing, via spliceosome recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay cell metabolism transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter positive regulation of translational initiation mRNA export from nucleus in response to heat stress fibroblast growth factor receptor signaling pathway snRNA transcription by RNA polymerase II RNA metabolic process regulation of gene silencing by miRNA DNA-templated transcription, initiation transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5433


69241

Ensembl


ENSG00000144231


ENSMUSG00000024258

UniProt


O15514


Q9D7M8

RefSeq (mRNA)


NM_004805


NM_027002 NM_001357480

RefSeq (protein)


NP_004796


NP_081278 NP_001344409

Location (UCSC)

Chr 2: 127.84 – 127.86 Mb

Chr 18: 31.92 – 31.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D gene.^[5]

This gene encodes the fourth-largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144231 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024258 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Khazak V, Estojak J, Cho H, Majors J, Sonoda G, Testa JR, Golemis EA (May 1998). "Analysis of the interaction of the novel RNA polymerase II (pol II) subunit hsRPB4 with its partner hsRPB7 and with pol II". Mol Cell Biol. 18 (4): 1935–45. doi:10.1128/mcb.18.4.1935. PMC 121423. PMID 9528765.
^ "Entrez Gene: POLR2D polymerase (RNA) II (DNA directed) polypeptide D".

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