RNF31

Protein-coding gene in the species Homo sapiens
RNF31
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CT7, 4DBG, 4JUY, 4LJO, 4LJP, 4LJQ, 4OWF, 4OYJ, 4OYK, 4P09, 4P0A, 4P0B, 5EDV

Identifiers
AliasesRNF31, HOIP, ZIBRA, ring finger protein 31, Paul
External IDsOMIM: 612487; MGI: 1934704; HomoloGene: 33228; GeneCards: RNF31; OMA:RNF31 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for RNF31
Genomic location for RNF31
Band14q12Start24,146,683 bp[1]
End24,160,660 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for RNF31
Genomic location for RNF31
Band14|14 C3Start55,829,165 bp[2]
End55,841,150 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • granulocyte

  • apex of heart

  • blood

  • muscle of thigh

  • right lobe of thyroid gland

  • anterior pituitary

  • body of pancreas

  • left lobe of thyroid gland

  • right ovary
Top expressed in
  • granulocyte

  • neural layer of retina

  • internal carotid artery

  • mesenteric lymph nodes

  • muscle of thigh

  • yolk sac

  • duodenum

  • jejunum

  • thymus

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • ubiquitin-protein transferase activity
  • ubiquitin binding
  • protein binding
  • ubiquitin protein ligase binding
  • transferase activity
Cellular component
  • cytoplasm
  • cytosol
  • LUBAC complex
  • CD40 receptor complex
  • cytoplasmic side of plasma membrane
Biological process
  • positive regulation of protein targeting to mitochondrion
  • CD40 signaling pathway
  • regulation of tumor necrosis factor-mediated signaling pathway
  • protein polyubiquitination
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • I-kappaB kinase/NF-kappaB signaling
  • T cell receptor signaling pathway
  • protein linear polyubiquitination
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55072

268749

Ensembl

ENSG00000092098
ENSG00000285152

ENSMUSG00000047098

UniProt

Q96EP0

Q924T7

RefSeq (mRNA)

NM_017999
NM_001310332

NM_194346

RefSeq (protein)

NP_001297261
NP_060469

NP_919327

Location (UCSC)Chr 14: 24.15 – 24.16 MbChr 14: 55.83 – 55.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 31 is a protein that in humans is encoded by the RNF31 gene.[5][6]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.[6]

See also

References

  1. ^ a b c ENSG00000285152 GRCh38: Ensembl release 89: ENSG00000092098, ENSG00000285152 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047098 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ van der Reijden BA, Erpelinck-Verschueren CA, Lowenberg B, Jansen JH (Sep 1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557–61. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847.
  6. ^ a b "Entrez Gene: RNF31 ring finger protein 31".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Saurin AJ, Borden KL, Boddy MN, Freemont PS (1996). "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. doi:10.1016/s0968-0004(96)80017-x. PMID 8744354.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Thompson HG, Harris JW, Lin L, Brody JP (2004). "Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells". Exp. Cell Res. 295 (2): 448–59. doi:10.1016/j.yexcr.2004.01.019. PMID 15093743.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Kirisako T, Kamei K, Murata S, et al. (2006). "A ubiquitin ligase complex assembles linear polyubiquitin chains". EMBO J. 25 (20): 4877–87. doi:10.1038/sj.emboj.7601360. PMC 1618115. PMID 17006537.
  • v
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  • 2ct7: Solution Structure of the IBR domain of the RING finger protein 31 protein
    2ct7: Solution Structure of the IBR domain of the RING finger protein 31 protein


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