RRAGA

Protein-coding gene in the species Homo sapiens
RRAGA
Identifiers
AliasesRRAGA, FIP-1, FIP1, RAGA, Ras related GTP binding A
External IDsOMIM: 612194; MGI: 1915691; HomoloGene: 68522; GeneCards: RRAGA; OMA:RRAGA - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for RRAGA
Genomic location for RRAGA
Band9p22.1Start19,049,427 bp[1]
End19,051,025 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for RRAGA
Genomic location for RRAGA
Band4|4 C4Start86,493,905 bp[2]
End86,495,522 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • paraflocculus of cerebellum

  • frontal pole

  • Brodmann area 10

  • middle frontal gyrus

  • cerebellar vermis

  • islet of Langerhans

  • smooth muscle tissue

  • Skeletal muscle tissue of biceps brachii

  • Skeletal muscle tissue of rectus abdominis

  • Brodmann area 9
Top expressed in
  • zygote

  • secondary oocyte

  • dorsomedial hypothalamic nucleus

  • visual cortex

  • primary visual cortex

  • superior frontal gyrus

  • lateral hypothalamus

  • paraventricular nucleus of hypothalamus

  • choroid plexus of fourth ventricle

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein homodimerization activity
  • GTP binding
  • phosphoprotein binding
  • protein binding
  • GTPase activity
  • ubiquitin protein ligase binding
  • protein heterodimerization activity
Cellular component
  • cytoplasm
  • cytosol
  • GATOR1 complex
  • lysosomal membrane
  • lysosome
  • nucleus
  • Gtr1-Gtr2 GTPase complex
Biological process
  • cellular response to amino acid starvation
  • cell death
  • positive regulation of cytolysis
  • positive regulation of TORC1 signaling
  • modulation by virus of host process
  • cellular response to amino acid stimulus
  • viral process
  • negative regulation of autophagy
  • positive regulation of TOR signaling
  • apoptotic process
  • protein ubiquitination
  • regulation of macroautophagy
  • cellular response to starvation
  • regulation of autophagy
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10670

68441

Ensembl

ENSG00000155876

ENSMUSG00000070934

UniProt

Q7L523

Q80X95

RefSeq (mRNA)

NM_006570

NM_178376

RefSeq (protein)

NP_006561

NP_848463

Location (UCSC)Chr 9: 19.05 – 19.05 MbChr 4: 86.49 – 86.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.[5][6][7]

Interactions

RRAGA has been shown to interact with NOL8[8] and RRAGC.[9][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155876 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070934 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
  6. ^ Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology. 71 (2): 1576–82. doi:10.1128/JVI.71.2.1576-1582.1997. PMC 191215. PMID 8995684.
  7. ^ "Entrez Gene: RRAGA Ras-related GTP binding A".
  8. ^ Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  10. ^ Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

Further reading

  • Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Jan 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". Journal of Cell Science. 111 ( Pt 1) (1): 11–21. doi:10.1242/jcs.111.1.11. PMID 9394008.
  • Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
  • Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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