RSF1

Protein-coding gene in the species Homo sapiens
RSF1
Identifiers
AliasesRSF1, HBXAP, RSF-1, XAP8, p325, remodeling and spacing factor 1
External IDsOMIM: 608522; MGI: 2682305; HomoloGene: 41142; GeneCards: RSF1; OMA:RSF1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RSF1
Genomic location for RSF1
Band11q14.1Start77,660,009 bp[1]
End77,820,869 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for RSF1
Genomic location for RSF1
Band7|7 E1Start97,229,096 bp[2]
End97,341,985 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • internal globus pallidus

  • sural nerve

  • epithelium of colon

  • tendon of biceps brachii

  • cerebellar vermis

  • Brodmann area 23

  • pars reticulata

  • middle temporal gyrus

  • external globus pallidus
Top expressed in
  • hand

  • Rostral migratory stream

  • tail of embryo

  • genital tubercle

  • ventromedial nucleus

  • lateral septal nucleus

  • otolith organ

  • olfactory tubercle

  • utricle

  • maxillary prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • histone binding
  • ATPase activity
  • protein binding
  • metal ion binding
  • histone acetyltransferase activity
Cellular component
  • RSF complex
  • nucleus
  • nucleoplasm
  • histone acetyltransferase complex
Biological process
  • positive regulation of transcription, DNA-templated
  • negative regulation of DNA binding
  • chromatin remodeling
  • positive regulation of viral transcription
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • CENP-A containing chromatin assembly
  • transcription, DNA-templated
  • DNA-templated transcription, initiation
  • nucleosome assembly
  • chromatin organization
  • histone acetylation
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51773

233532

Ensembl

ENSG00000048649

ENSMUSG00000035623

UniProt

Q96T23
Q05DG0

n/a

RefSeq (mRNA)

NM_016578

NM_001081267

RefSeq (protein)

NP_057662
NP_057662.3

n/a

Location (UCSC)Chr 11: 77.66 – 77.82 MbChr 7: 97.23 – 97.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.[5][6][7]

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000048649 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035623 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (Mar 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J Biol Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
  6. ^ Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Sep 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
  7. ^ a b "Entrez Gene: RSF1 remodeling and spacing factor 1".

Further reading

  • Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein". J. Virol. 69 (2): 1107–14. doi:10.1128/JVI.69.2.1107-1114.1995. PMC 188683. PMID 7815490.
  • LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science. 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
  • Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity". Genomics. 79 (4): 523–9. doi:10.1006/geno.2002.6717. PMID 11944984.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
  • Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB". Exp. Cell Res. 298 (1): 133–43. doi:10.1016/j.yexcr.2004.04.019. PMID 15242768.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. Bibcode:2005PNAS..10214004S. doi:10.1073/pnas.0504195102. PMC 1236547. PMID 16172393.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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