Ro 3-0422
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Preferred IUPAC name 3-[(Diethoxyphosphoryl)oxy]-1-methylquinolin-1-ium methyl sulfate | |
Other names 3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate | |
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Properties | |
Chemical formula | C15H22NO8PS |
Molar mass | 407.37 g·mol−1 |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards | Extremely toxic |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | 20 μg/kg (mice, intravenous) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous LD50 is 20 μg/kg in mice.[1] It is over 300 times more potent than neostigmine.[2]
See also
- Ro 3-0419
References
- ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.
- ^ Andrews, K. J. M.; Atherton, F. R.; Bergel, F.; Morrison, A. L. (1954). "Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases". Journal of the Chemical Society (Resumed): 1638. doi:10.1039/jr9540001638.
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Acetylcholine metabolism and transport modulators
(modulators)
(modulators)
CHTTooltip Choline transporter |
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VAChTTooltip Vesicular acetylcholine transporter |
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(modulators)
Inhibitors |
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Enhancers |
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- See also
- Receptor/signaling modulators
- Muscarinic acetylcholine receptor modulators
- Nicotinic acetylcholine receptor modulators
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