SAP18

Protein-coding gene in the species Homo sapiens

SAP18

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
2HDE

Identifiers

Aliases

SAP18, 2HOR0202, SAP18P, Sin3A associated protein 18kDa, Sin3A associated protein 18

External IDs

OMIM: 602949; MGI: 3704317; HomoloGene: 4289; GeneCards: SAP18; OMA:SAP18 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q12.11	Start	21,140,514 bp^[1]
Band	13q12.11	End	21,149,084 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 D1	Start	96,551,974 bp^[2]
Band	8\|8 D1	End	96,552,762 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

internal globus pallidus

right ventricle

tendon

tendon of biceps brachii

corpus epididymis

Achilles tendon

caput epididymis

bronchial epithelial cell

biceps brachii

Skeletal muscle tissue of biceps brachii

Top expressed in

primary oocyte

yolk sac

embryo

embryo

neural tube

stomach

lens

zygote

epiblast

proximal tubule

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transcription corepressor activity protein binding histone deacetylase activity RNA binding
Cellular component	histone deacetylase complex nuclear speck exon-exon junction complex nucleoplasm ASAP complex nucleus cytoplasm cytosol nuclear body
Biological process	regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II mRNA processing regulation of alternative mRNA splicing, via spliceosome transcription, DNA-templated negative regulation of mRNA splicing, via spliceosome RNA splicing positive regulation of apoptotic process negative regulation of nucleic acid-templated transcription histone deacetylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10284


100041953

Ensembl


ENSG00000150459


ENSMUSG00000061104

UniProt


O00422


n/a

RefSeq (mRNA)


NM_005870 NM_001366643


NM_001142441

RefSeq (protein)


NP_005861 NP_001353572


n/a

Location (UCSC)

Chr 13: 21.14 – 21.15 Mb

Chr 8: 96.55 – 96.55 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Histone deacetylase complex subunit SAP18 is an enzyme that in humans is encoded by the SAP18 gene.^[5]^[6]

Function

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Multisubunit complexes catalyze histone acetylation and deacetylation. The protein encoded by this gene is a histone deacetylase complex component, including SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.^[6] Additionally, SAP18s splice variants are implicated in apoptotic cycles.^[7]

Interactions

SAP18 has been shown to interact with

POLE2,^[8]^[9] and
RGS10.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150459 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061104 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
^ ^a ^b "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa".
^ Michelle L, Cloutier A, Toutant J, Shkreta L, Thibault P, Durand M, Garneau D, Gendron D, Lapointe E, Couture S, Le Hir H, Klinck R, Elela SA, Prinos P, Chabot B (March 2012). "Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators". Molecular and Cellular Biology. 32 (5): 954–67. doi:10.1128/MCB.06130-11. PMC 3295189. PMID 22203037.
^ Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (March 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". Journal of Biochemistry. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
^ Cheng SY, Bishop JM (April 2002). "Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5442–7. Bibcode:2002PNAS...99.5442C. doi:10.1073/pnas.082096999. PMC 122788. PMID 11960000.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.