SESN3

Protein-coding gene in the species Homo sapiens
SESN3
Identifiers
AliasesSESN3, SEST3, sestrin 3
External IDsOMIM: 607768; MGI: 1922997; HomoloGene: 14386; GeneCards: SESN3; OMA:SESN3 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SESN3
Genomic location for SESN3
Band11q21Start95,165,513 bp[1]
End95,232,541 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SESN3
Genomic location for SESN3
Band9|9 A1Start14,186,363 bp[2]
End14,244,397 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • lateral nuclear group of thalamus

  • retinal pigment epithelium

  • internal globus pallidus

  • trigeminal ganglion

  • mucosa of paranasal sinus

  • epithelium of nasopharynx

  • Achilles tendon

  • spinal ganglia

  • external globus pallidus
Top expressed in
  • ventromedial nucleus

  • lateral septal nucleus

  • molar

  • olfactory tubercle

  • saccule

  • mammillary body

  • ciliary body

  • nucleus accumbens

  • amygdala

  • retinal pigment epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • oxidoreductase activity
  • protein binding
  • oxidoreductase activity, acting on peroxide as acceptor
  • leucine binding
Cellular component
  • nucleus
  • cytoplasm
  • GATOR2 complex
  • TORC2 complex
Biological process
  • regulation of response to reactive oxygen species
  • negative regulation of TORC1 signaling
  • response to insulin
  • glucose homeostasis
  • regulation of protein kinase B signaling
  • TORC2 signaling
  • regulation of insulin receptor signaling pathway
  • cellular response to amino acid starvation
  • cellular response to glucose starvation
  • cellular response to amino acid stimulus
  • positive regulation of macroautophagy
  • cellular response to leucine
  • cellular response to leucine starvation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

143686

75747

Ensembl

ENSG00000149212

ENSMUSG00000032009

UniProt

P58005

Q9CYP7

RefSeq (mRNA)

NM_001271594
NM_144665

NM_030261

RefSeq (protein)

NP_001258523
NP_653266

NP_084537

Location (UCSC)Chr 11: 95.17 – 95.23 MbChr 9: 14.19 – 14.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sestrin 3 is a protein that in humans is encoded by the SESN3 gene. [5]

Function

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149212 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032009 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Sestrin 3". Retrieved 2017-08-05.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). "FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor". Dev. Cell. 18 (4): 592–604. doi:10.1016/j.devcel.2010.03.008. PMC 3031984. PMID 20412774.
  • Zamkova M, Khromova N, Kopnin BP, Kopnin P (2013). "Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways". Cell Cycle. 12 (5): 826–36. doi:10.4161/cc.23723. PMC 3610730. PMID 23388456.
  • Nascimento EB, Osler ME, Zierath JR (2013). "Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 305 (11): E1408–14. doi:10.1152/ajpendo.00212.2013. PMC 3882372. PMID 24129397.
  • Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC (2013). "Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells". PLOS ONE. 8 (11): e78780. Bibcode:2013PLoSO...878780V. doi:10.1371/journal.pone.0078780. PMC 3832611. PMID 24260131.
  • Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S (2014). "The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury". Am. J. Physiol. Gastrointest. Liver Physiol. 307 (1): G58–65. doi:10.1152/ajpgi.00373.2013. PMC 4080163. PMID 24833709.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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