SKF-91488
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Preferred IUPAC name 4-(Dimethylamino)butyl carbamimidothioate | |
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Properties | |
Chemical formula | C7H17N3S |
Molar mass | 175.29 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels.[1][2]
See also
- α-Fluoromethylhistidine
- Histidine methyl ester
References
- ^ Thakkar, Mahesh M. (February 2011). "Histamine in the regulation of wakefulness". Sleep Medicine Reviews. 15 (1): 65–74. doi:10.1016/j.smrv.2010.06.004. PMC 3016451. PMID 20851648.
- ^ Tamaoki, J.; Chiyotani, A.; Tagaya, E.; Isono, K.; Konno, K. (1994). "Histamine N-methyltransferase Modulates Human Bronchial Smooth Muscle Contraction". Mediators of Inflammation. 3 (2): 125–129. doi:10.1155/S0962935194000153. PMC 2367027. PMID 18472930.
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Monoamine metabolism modulators
(dopamine, epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase |
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THTooltip Tyrosine hydroxylase |
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DBHTooltip Dopamine beta-monooxygenase |
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PNMTTooltip Phenylethanolamine N-methyltransferase |
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COMTTooltip Catechol-O-methyl transferase |
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(serotonin, melatonin)
TPHTooltip Tryptophan hydroxylase |
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AANATTooltip Serotonin N-acetyl transferase |
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ASMTTooltip Acetylserotonin O-methyltransferase |
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HDCTooltip Histidine decarboxylase |
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HNMTTooltip Histamine N-methyltransferase |
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DAOTooltip Diamine oxidase |
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See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins