SLC16A11

SLC16A11
Identifiers
AliasesSLC16A11, MCT11, solute carrier family 16 member 11, MCT 11
External IDsOMIM: 615765; MGI: 2663709; HomoloGene: 27409; GeneCards: SLC16A11; OMA:SLC16A11 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SLC16A11
Genomic location for SLC16A11
Band17p13.1Start7,041,621 bp[1]
End7,044,092 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SLC16A11
Genomic location for SLC16A11
Band11|11 B3Start70,103,578 bp[2]
End70,107,243 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • olfactory zone of nasal mucosa

  • parotid gland

  • minor salivary glands

  • palpebral conjunctiva

  • skin of abdomen

  • skin of leg

  • right lobe of liver
Top expressed in
  • cerebellar cortex

  • right kidney

  • olfactory epithelium

  • motor neuron

  • superior frontal gyrus

  • trachea

  • primary visual cortex

  • conjunctival fornix

  • dentate gyrus of hippocampal formation granule cell

  • gastrula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • symporter activity
  • monocarboxylic acid transmembrane transporter activity
  • protein binding
  • pyruvate transmembrane transporter activity
Cellular component
  • membrane
  • integral component of membrane
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • integral component of plasma membrane
  • plasma membrane
Biological process
  • transmembrane transport
  • lipid metabolism
  • monocarboxylic acid transport
  • pyruvate transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

162515

216867

Ensembl

ENSG00000174326

ENSMUSG00000040938

UniProt

Q8NCK7

Q5NC32

RefSeq (mRNA)

NM_153357
NM_001370549
NM_001370553

NM_001114970
NM_001114971
NM_153081

RefSeq (protein)

NP_699188
NP_001357478
NP_001357482

NP_694721

Location (UCSC)Chr 17: 7.04 – 7.04 MbChr 11: 70.1 – 70.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Monocarboxylate transporter 11 (MCT 11) is a protein that in humans is encode by the SLC16A11 gene.[5]

Variants in this gene are associated with increased body-mass index[6] and type 2 diabetes.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174326 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040938 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "UniProt". www.uniprot.org. Retrieved 2024-07-16.
  6. ^ Mardones L, Petermann-Rocha F, Martinez-Sanguinetti MA, Leiva AM, Troncoso-Pantoja C, Martorell M, et al. (November 2021). "Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population". Archives of Endocrinology and Metabolism. 65 (3): 305–314. doi:10.20945/2359-3997000000359. PMC 10065347. PMID 33909378.
  7. ^ Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, et al. (February 2014). "Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico". Nature. 506 (7486): 97–101. Bibcode:2014Natur.506...97T. doi:10.1038/nature12828. PMC 4127086. PMID 24390345.
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