Protein-coding gene in the species Homo sapiens
| SNX4 |
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| Identifiers |
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| Aliases | SNX4, ATG24B, sorting nexin 4 |
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| External IDs | OMIM: 605931; MGI: 1916400; HomoloGene: 36143; GeneCards: SNX4; OMA:SNX4 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 3 (human)[1] |
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| | Band | 3q21.2 | Start | 125,446,650 bp[1] |
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| End | 125,520,202 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 16 (mouse)[2] |
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| | Band | 16|16 B3 | Start | 33,071,812 bp[2] |
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| End | 33,120,639 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - secondary oocyte
- jejunal mucosa
- Achilles tendon
- kidney tubule
- ganglionic eminence
- ventricular zone
- islet of Langerhans
- duodenum
- Epithelium of choroid plexus
- tendon of biceps brachii
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| | Top expressed in | - atrioventricular valve
- left lung lobe
- endocardial cushion
- sciatic nerve
- granulocyte
- yolk sac
- vestibular sensory epithelium
- ureter
- primitive streak
- zygote
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | - insulin receptor binding
- leptin receptor binding
- epidermal growth factor receptor binding
- protein binding
- phosphatidylinositol binding
- transferrin receptor binding
- lipid binding
| | Cellular component | - cytoplasm
- extrinsic component of membrane
- endosome
- early endosome membrane
- membrane
- plasma membrane
- SNARE complex
- cytoplasmic dynein complex
- protein-containing complex
- early endosome
| | Biological process | - endocytosis
- vesicle organization
- endocytic recycling
- protein transport
- positive regulation of histamine secretion by mast cell
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 3: 125.45 – 125.52 Mb | Chr 16: 33.07 – 33.12 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.[5][6]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.[6]
Interactions
SNX4 has been shown to interact with BIN1.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
- ^ a b "Entrez Gene: SNX4 sorting nexin 4".
- ^ Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10). England: 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.
Further reading
- Traer CJ, Rutherford AC, Palmer KJ, et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment". Nat. Cell Biol. 9 (12): 1370–80. doi:10.1038/ncb1656. PMID 17994011. S2CID 23816176.
- Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic. 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. hdl:10852/11339. PMID 17319803. S2CID 21600584.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Leprince C, Le Scolan E, Meunier B, et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. PMID 12668730.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
| SNX-BAR | |
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| SNX-PX | - SNX3
- SNX10
- SNX11
- SNX12
- SNX16
- SNX20
- SNX21
- SNX22
- SNX24
- SNX29
|
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| SNX-Other | |
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| Related articles | |
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