SRPK2

Protein-coding gene in the species Homo sapiens
SRPK2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2X7G

Identifiers
AliasesSRPK2, SFRSK2, SRSF protein kinase 2
External IDsOMIM: 602980; MGI: 1201408; HomoloGene: 101663; GeneCards: SRPK2; OMA:SRPK2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SRPK2
Genomic location for SRPK2
Band7q22.3Start105,110,704 bp[1]
End105,399,308 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for SRPK2
Genomic location for SRPK2
Band5 A3|5 10.36 cMStart23,503,264 bp[2]
End23,684,617 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • pons

  • secondary oocyte

  • middle temporal gyrus

  • lateral nuclear group of thalamus

  • entorhinal cortex

  • parietal lobe

  • postcentral gyrus

  • left testis

  • right testis
Top expressed in
  • Rostral migratory stream

  • medial dorsal nucleus

  • medial geniculate nucleus

  • ventral tegmental area

  • spermatid

  • lateral geniculate nucleus

  • seminiferous tubule

  • pontine nuclei

  • medial vestibular nucleus

  • globus pallidus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • protein kinase activity
  • 14-3-3 protein binding
  • kinase activity
  • protein serine/threonine kinase activity
  • protein binding
  • ATP binding
  • magnesium ion binding
  • RNA binding
Cellular component
  • cytoplasm
  • nucleoplasm
  • nucleolus
  • nucleus
  • cytosol
Biological process
  • cell differentiation
  • intracellular signal transduction
  • nuclear speck organization
  • phosphorylation
  • mRNA processing
  • regulation of mRNA splicing, via spliceosome
  • protein phosphorylation
  • spliceosomal complex assembly
  • positive regulation of neuron apoptotic process
  • negative regulation of viral genome replication
  • positive regulation of gene expression
  • positive regulation of cell cycle
  • angiogenesis
  • RNA splicing
  • positive regulation of cell population proliferation
  • positive regulation of viral genome replication
  • innate immune response
  • regulation of gene expression
  • regulation of mRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6733

20817

Ensembl

ENSG00000135250

ENSMUSG00000062604

UniProt

P78362

O54781

RefSeq (mRNA)
NM_001278273
NM_182691
NM_182692
NM_001350738
NM_001350739

NM_001350740
NM_001350741
NM_001350742
NM_001350743
NM_001350744
NM_001350745
NM_001350746

NM_009274
NM_001359172
NM_001359173
NM_001359174
NM_001359175

NM_001359176

RefSeq (protein)
NP_001265202
NP_872633
NP_872634
NP_001337667
NP_001337668

NP_001337669
NP_001337670
NP_001337671
NP_001337672
NP_001337673
NP_001337674
NP_001337675

NP_033300
NP_001346101
NP_001346102
NP_001346103
NP_001346104

NP_001346105
NP_001394425
NP_001394427
NP_001394428
NP_001394429
NP_001394430
NP_001394431
NP_001394432
NP_001394433
NP_001394434
NP_001394435
NP_001394436
NP_001394437
NP_001394438
NP_001394439
NP_001394440
NP_001394441
NP_001394442
NP_001394443
NP_001394444
NP_001394445
NP_001394446
NP_001394447
NP_001394448
NP_001394449
NP_001394450
NP_001394451
NP_001394452

Location (UCSC)Chr 7: 105.11 – 105.4 MbChr 5: 23.5 – 23.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene.[5][6][7]

Interactions

SRPK2 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135250 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062604 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-13.
  6. ^ a b c Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (Mar 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757. PMID 9472028.
  7. ^ "Entrez Gene: SRPK2 SFRS protein kinase 2".
  8. ^ Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/s0006-291x(02)03017-6. PMID 12565863.
  9. ^ Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (Apr 1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi:10.1074/jbc.274.16.11125. PMID 10196197.
  10. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands". EMBO J. 16 (9): 2376–83. doi:10.1093/emboj/16.9.2376. PMC 1169838. PMID 9171351.
  • Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M (1998). "Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles". Biochem. Biophys. Res. Commun. 242 (2): 357–64. doi:10.1006/bbrc.1997.7913. PMID 9446799.
  • Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi:10.1074/jbc.274.16.11125. PMID 10196197.
  • Daub H, Blencke S, Habenberger P, Kurtenbach A, Dennenmoser J, Wissing J, Ullrich A, Cotten M (2002). "Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein". J. Virol. 76 (16): 8124–37. doi:10.1128/JVI.76.16.8124-8137.2002. PMC 155132. PMID 12134018.
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Zheng Y, Fu XD, Ou JH (2005). "Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein". Virology. 342 (1): 150–8. doi:10.1016/j.virol.2005.07.030. PMID 16122776.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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