STAP1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1X1F, 3MAZ |
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Identifiers |
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Aliases | STAP1, BRDG1, STAP-1, signal transducing adaptor family member 1 |
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External IDs | OMIM: 604298; MGI: 1926193; HomoloGene: 8103; GeneCards: STAP1; OMA:STAP1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4q13.2 | Start | 67,558,727 bp[1] |
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End | 67,607,337 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 E1 | Start | 86,219,605 bp[2] |
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End | 86,253,984 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - lymph node
- epithelium of nasopharynx
- spleen
- appendix
- granulocyte
- bone marrow cells
- testicle
- tonsil
- superficial temporal artery
- blood
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| Top expressed in | - granulocyte
- thymus
- spleen
- mesenteric lymph nodes
- olfactory epithelium
- blood
- lumbar spinal ganglion
- subcutaneous adipose tissue
- tibiofemoral joint
- lumbar subsegment of spinal cord
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - macrophage colony-stimulating factor receptor binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- phosphotyrosine residue binding
- receptor tyrosine kinase binding
- protein binding
- phospholipid binding
- protein kinase binding
- signaling adaptor activity
| Cellular component | - cytoplasm
- mitochondrion
- nucleus
- nucleoplasm
- intracellular membrane-bounded organelle
- protein-containing complex
| Biological process | - positive regulation of B cell receptor signaling pathway
- positive regulation of phagocytosis, engulfment
- transmembrane receptor protein tyrosine kinase signaling pathway
- negative regulation of ruffle assembly
- positive regulation of microglial cell mediated cytotoxicity
- positive regulation of non-membrane spanning protein tyrosine kinase activity
- negative regulation of microglial cell migration
- positive regulation of gene expression
- positive regulation of microglial cell activation
- negative regulation of phosphorylation
- cellular response to lipopolysaccharide
- negative regulation of macrophage colony-stimulating factor signaling pathway
- positive regulation of actin cytoskeleton reorganization
- negative regulation of macrophage chemotaxis
- response to bacterium
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 4: 67.56 – 67.61 Mb | Chr 5: 86.22 – 86.25 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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