SYTL1

Protein-coding gene in the species Homo sapiens

SYTL1
Identifiers
AliasesSYTL1, JFC1, SLP1, synaptotagmin like 1
External IDsOMIM: 608042; MGI: 1933365; HomoloGene: 12853; GeneCards: SYTL1; OMA:SYTL1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SYTL1
Genomic location for SYTL1
Band1p36.11Start27,342,020 bp[1]
End27,353,937 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SYTL1
Genomic location for SYTL1
Band4|4 D2.3Start132,980,401 bp[2]
End132,990,424 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • right uterine tube

  • body of pancreas

  • skin of abdomen

  • skin of arm

  • olfactory zone of nasal mucosa

  • skin of leg

  • gingival epithelium

  • spleen

  • cerebellar hemisphere
Top expressed in
  • esophagus

  • lip

  • transitional epithelium of urinary bladder

  • granulocyte

  • molar

  • skin of abdomen

  • skin of external ear

  • skin of back

  • pyloric antrum

  • left colon
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium-dependent phospholipid binding
  • clathrin binding
  • calcium ion binding
  • neurexin family protein binding
  • syntaxin binding
  • protein binding
Cellular component
  • melanosome
  • plasma membrane
  • extrinsic component of plasma membrane
  • extracellular exosome
  • exocytic vesicle
  • membrane
  • presynapse
  • microvillus membrane
Biological process
  • intracellular protein transport
  • exocytosis
  • calcium ion-regulated exocytosis of neurotransmitter
  • vesicle fusion
  • regulation of calcium ion-dependent exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84958

269589

Ensembl

ENSG00000142765

ENSMUSG00000028860

UniProt

Q8IYJ3

Q99N80

RefSeq (mRNA)

NM_001193308
NM_032872

NM_031393

RefSeq (protein)

NP_001180237
NP_116261

n/a

Location (UCSC)Chr 1: 27.34 – 27.35 MbChr 4: 132.98 – 132.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene.[5][6]

Interactions

SYTL1 has been shown to interact with RAB27A.[7][8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142765 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028860 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Catz SD, Babior BM, Johnson JL (November 2002). "JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells". The Biochemical Journal. 367 (Pt 3): 791–9. doi:10.1042/BJ20020345. PMC 1222920. PMID 12137562.
  6. ^ "Entrez Gene: SYTL1 synaptotagmin-like 1".
  7. ^ Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". The Journal of Biological Chemistry. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
  8. ^ Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". The Journal of Biological Chemistry. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
  9. ^ Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.

Further reading

  • Fukuda M, Mikoshiba K (March 2001). "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins". Biochemical and Biophysical Research Communications. 281 (5): 1226–33. doi:10.1006/bbrc.2001.4512. PMID 11243866.
  • McAdara Berkowitz JK, Catz SD, Johnson JL, Ruedi JM, Thon V, Babior BM (June 2001). "JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase". The Journal of Biological Chemistry. 276 (22): 18855–62. doi:10.1074/jbc.M011167200. PMID 11278853.
  • Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
  • Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". The Journal of Biological Chemistry. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
  • Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". The Journal of Biological Chemistry. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
  • Johnson JL, Ellis BA, Noack D, Seabra MC, Catz SD (November 2005). "The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase". The Biochemical Journal. 391 (Pt 3): 699–710. doi:10.1042/BJ20050380. PMC 1276972. PMID 16004602.
  • Schmid M, Fellermann K, Fritz P, Wiedow O, Stange EF, Wehkamp J (April 2007). "Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease". Journal of Leukocyte Biology. 81 (4): 907–15. doi:10.1189/jlb.0906581. PMID 17200145. S2CID 30032616.