SYTL2

Protein-coding gene in the species Homo sapiens

SYTL2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
3BC1

Identifiers

Aliases

SYTL2, CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A, synaptotagmin like 2

External IDs

OMIM: 612880; MGI: 1933366; HomoloGene: 131343; GeneCards: SYTL2; OMA:SYTL2 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q14.1	Start	85,694,224 bp^[1]
Band	11q14.1	End	85,811,159 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E1	Start	89,951,460 bp^[2]
Band	7\|7 E1	End	90,059,927 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

saphenous vein

rectum

mucosa of sigmoid colon

bronchial epithelial cell

endothelial cell

urethra

vena cava

right coronary artery

tibial arteries

mucosa of transverse colon

Top expressed in

iris

epithelium of stomach

pyloric antrum

transitional epithelium of urinary bladder

motor neuron

mucous cell of stomach

facial motor nucleus

zygote

hair follicle

secondary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium ion binding phosphatase binding clathrin binding phosphatidylserine binding neurexin family protein binding protein binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding syntaxin binding
Cellular component	cytoplasm exocytic vesicle membrane melanosome plasma membrane extrinsic component of plasma membrane synapse presynapse
Biological process	negative regulation of phosphatase activity vesicle docking involved in exocytosis protein localization to plasma membrane intracellular protein transport positive regulation of mucus secretion vesicle-mediated transport exocytosis regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter vesicle fusion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54843


83671

Ensembl


ENSG00000137501


ENSMUSG00000030616

UniProt


Q9HCH5


Q99N50

RefSeq (mRNA)

NM_001162951 NM_001162952 NM_001162953 NM_001289608 NM_001289609
NM_001289610 NM_032379 NM_032943 NM_206927 NM_206928 NM_206929 NM_206930 NM_001365826 NM_001365827 NM_001365828 NM_001365829 NM_001365830 NM_001365831 NM_001365832 NM_001365833 NM_001365834 NM_001365835

NM_001040085 NM_001040086 NM_001040087 NM_001040088 NM_001289583
NM_001289584 NM_001289585 NM_001289586 NM_031394 NM_001368878

RefSeq (protein)

NP_001156423 NP_001156424 NP_001156425 NP_001276537 NP_001276538
NP_001276539 NP_116561 NP_996812 NP_996813 NP_001352755 NP_001352756 NP_001352757 NP_001352758 NP_001352759 NP_001352760 NP_001352761 NP_001352762 NP_001352763 NP_001352764 NP_996810 NP_996811

NP_001035174 NP_001035176 NP_001035177 NP_001276512 NP_001276513
NP_001276514 NP_001276515 NP_113571 NP_001355807

Location (UCSC)

Chr 11: 85.69 – 85.81 Mb

Chr 7: 89.95 – 90.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Synaptotagmin-like 2, also known as SYTL2, is a human gene.^[5]

Function

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.^[5]

Interactions

SYTL2 has been shown to interact with RAB27A.^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137501 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030616 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SYTL2 synaptotagmin-like 2".
^ Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". The Journal of Biological Chemistry. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
^ Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". The Journal of Biological Chemistry. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
^ Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.

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