SYTL4

Protein-coding gene in the species Homo sapiens
SYTL4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CSZ, 3FDW

Identifiers
AliasesSYTL4, SLP4, synaptotagmin like 4
External IDsOMIM: 300723; MGI: 1351606; HomoloGene: 8454; GeneCards: SYTL4; OMA:SYTL4 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SYTL4
Genomic location for SYTL4
BandXq22.1Start100,674,491 bp[1]
End100,732,123 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for SYTL4
Genomic location for SYTL4
BandX|X E3Start132,837,134 bp[2]
End132,882,561 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ovary

  • right ovary

  • body of uterus

  • canal of the cervix

  • left uterine tube

  • pituitary gland

  • anterior pituitary

  • myometrium

  • ectocervix

  • smooth muscle tissue
Top expressed in
  • superior cervical ganglion

  • islet of Langerhans

  • zygote

  • secondary oocyte

  • primary oocyte

  • pituitary gland

  • blood

  • epithelium of stomach

  • cumulus cell

  • ovary
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium ion binding
  • clathrin binding
  • metal ion binding
  • protein binding
  • calcium-dependent phospholipid binding
  • syntaxin binding
  • phospholipid binding
  • neurexin family protein binding
Cellular component
  • endosome
  • exocytic vesicle
  • membrane
  • transport vesicle membrane
  • secretory granule
  • nucleoplasm
  • cytoplasmic vesicle
  • presynapse
  • extrinsic component of membrane
  • microtubule organizing center
  • cytosol
  • plasma membrane
  • platelet alpha granule membrane
  • synapse
Biological process
  • negative regulation of insulin secretion
  • multivesicular body sorting pathway
  • positive regulation of protein secretion
  • positive regulation of exocytosis
  • intracellular protein transport
  • exocytosis
  • vesicle fusion
  • regulation of calcium ion-dependent exocytosis
  • calcium ion-regulated exocytosis of neurotransmitter
  • platelet degranulation
  • plasma membrane repair
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

94121

27359

Ensembl

ENSG00000102362

ENSMUSG00000031255

UniProt

Q96C24

Q9R0Q1

RefSeq (mRNA)

NM_001129896
NM_001174068
NM_080737

NM_001290717
NM_001290718
NM_001290719
NM_013757

RefSeq (protein)
NP_001123368
NP_001167539
NP_542775
NP_001357089
NP_001357090

NP_001357091
NP_001357092
NP_001357093
NP_001357094
NP_001357095
NP_001357096
NP_001357097
NP_001357098

NP_001277646
NP_001277647
NP_001277648
NP_038785

Location (UCSC)Chr X: 100.67 – 100.73 MbChr X: 132.84 – 132.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102362 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031255 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SYTL4 synaptotagmin-like 4 (granuphilin-a)".

Further reading

  • Wang J, Takeuchi T, Yokota H, Izumi T (1999). "Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells". J. Biol. Chem. 274 (40): 28542–8. doi:10.1074/jbc.274.40.28542. PMID 10497219.
  • Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
  • Yi Z, Yokota H, Torii S, et al. (2002). "The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules". Mol. Cell. Biol. 22 (6): 1858–67. doi:10.1128/MCB.22.6.1858-1867.2002. PMC 135591. PMID 11865063.
  • Zhao S, Torii S, Yokota-Hashimoto H, et al. (2002). "Involvement of Rab27b in the regulated secretion of pituitary hormones". Endocrinology. 143 (5): 1817–24. doi:10.1210/endo.143.5.8823. PMID 11956164.
  • Torii S, Zhao S, Yi Z, et al. (2002). "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a". Mol. Cell. Biol. 22 (15): 5518–26. doi:10.1128/MCB.22.15.5518-5526.2002. PMC 133943. PMID 12101244.
  • Fukuda M, Kanno E, Saegusa C, et al. (2002). "Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells". J. Biol. Chem. 277 (42): 39673–8. doi:10.1074/jbc.M205349200. PMID 12176990.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ciufo LF, Barclay JW, Burgoyne RD, Morgan A (2005). "Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions". Mol. Biol. Cell. 16 (2): 470–82. doi:10.1091/mbc.E04-08-0685. PMC 545880. PMID 15563604.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Plaisance V, Abderrahmani A, Perret-Menoud V, et al. (2006). "MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells". J. Biol. Chem. 281 (37): 26932–42. doi:10.1074/jbc.M601225200. PMID 16831872.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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  • 2csz: Solution Structure of the RING domain of the Synaptotagmin-like protein 4
    2csz: Solution Structure of the RING domain of the Synaptotagmin-like protein 4


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