Sodium- and chloride-dependent taurine transporter

Protein
SLC6A6
Identifiers
AliasesSLC6A6, TAUT, solute carrier family 6 member 6, HTRDC
External IDsOMIM: 186854; MGI: 98488; HomoloGene: 2291; GeneCards: SLC6A6; OMA:SLC6A6 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SLC6A6
Genomic location for SLC6A6
Band3p25.1Start14,402,576 bp[1]
End14,489,349 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for SLC6A6
Genomic location for SLC6A6
Band6 D1|6 40.73 cMStart91,684,053 bp[2]
End91,759,066 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of paranasal sinus

  • palpebral conjunctiva

  • olfactory zone of nasal mucosa

  • blood

  • visceral pleura

  • bronchial epithelial cell

  • epithelium of nasopharynx

  • monocyte

  • skin of hip

  • germinal epithelium
Top expressed in
  • ciliary body

  • neural layer of retina

  • iris

  • skin of external ear

  • calvaria

  • retinal pigment epithelium

  • ankle joint

  • gastrula

  • decidua

  • stroma of bone marrow
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • neurotransmitter:sodium symporter activity
  • symporter activity
  • amino acid transmembrane transporter activity
  • taurine:sodium symporter activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • cellular amino acid metabolic process
  • amino acid transmembrane transport
  • neurotransmitter transport
  • amino acid transport
  • taurine transport
  • transmembrane transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6533

21366

Ensembl

ENSG00000131389

ENSMUSG00000030096

UniProt

P31641

O35316

RefSeq (mRNA)

NM_001134367
NM_001134368
NM_003043

NM_009320

RefSeq (protein)

NP_001127839
NP_001127840
NP_003034

NP_033346

Location (UCSC)Chr 3: 14.4 – 14.49 MbChr 6: 91.68 – 91.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131389 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030096 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V (Jul 1994). "Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta". Biochem J. 300 (3): 893–900. doi:10.1042/bj3000893. PMC 1138249. PMID 8010975.
  6. ^ Jhiang SM, Fithian L, Smanik P, McGill J, Tong Q, Mazzaferri EL (Mar 1993). "Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells". FEBS Lett. 318 (2): 139–44. doi:10.1016/0014-5793(93)80008-I. PMID 8382624. S2CID 28368668.
  7. ^ "Entrez Gene: SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6".

Further reading

  • Uchida S, Kwon HM, Yamauchi A, et al. (1992). "Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(−)-dependent taurine transporter that is regulated by hypertonicity". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8230–4. Bibcode:1992PNAS...89.8230U. doi:10.1073/pnas.89.17.8230. PMC 49891. PMID 1518851.
  • Miyamoto Y, Liou GI, Sprinkle TJ (1996). "Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium". Curr. Eye Res. 15 (3): 345–9. doi:10.3109/02713689609007631. PMID 8654117.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Mochizuki T, Satsu H, Shimizu M (2002). "Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells". FEBS Lett. 517 (1–3): 92–6. doi:10.1016/S0014-5793(02)02584-X. PMID 12062416. S2CID 86171679.
  • Han X, Patters AB, Chesney RW (2002). "Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells". J. Biol. Chem. 277 (42): 39266–73. doi:10.1074/jbc.M205939200. PMID 12163498.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Han X, Chesney RW (2003). "Regulation of taurine transporter gene (TauT) by WT1". FEBS Lett. 540 (1–3): 71–6. doi:10.1016/S0014-5793(03)00227-8. PMID 12681485. S2CID 32139788.
  • Roos S, Powell TL, Jansson T (2004). "Human placental taurine transporter in uncomplicated and IUGR pregnancies: cellular localization, protein expression, and regulation". Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 (4): R886–93. CiteSeerX 10.1.1.1026.3853. doi:10.1152/ajpregu.00232.2004. PMID 15166008.
  • Satsu H, Manabe M, Shimizu M (2004). "Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter". FEBS Lett. 569 (1–3): 123–8. doi:10.1016/j.febslet.2004.05.062. PMID 15225620. S2CID 11395494.
  • Mochizuki T, Satsu H, Nakano T, Shimizu M (2005). "Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells". BioFactors. 21 (1–4): 141–4. doi:10.1002/biof.552210128. PMID 15630186. S2CID 35504141.
  • Mochizuki T, Satsu H, Shimizu M (2005). "Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells". FEBS Lett. 579 (14): 3069–74. doi:10.1016/j.febslet.2005.04.063. PMID 15907840. S2CID 84235462.
  • Nakashima E, Pop-Busui R, Towns R, et al. (2006). "Regulation of the human taurine transporter by oxidative stress in retinal pigment epithelial cells stably transformed to overexpress aldose reductase" (PDF). Antioxid. Redox Signal. 7 (11–12): 1530–42. doi:10.1089/ars.2005.7.1530. hdl:2027.42/63284. PMID 16356117.
  • Iruloh CG, D'Souza SW, Speake PF, et al. (2007). "Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity". Am. J. Physiol., Cell Physiol. 292 (1): C332–41. doi:10.1152/ajpcell.00634.2005. PMID 16956961.


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