Protein-coding gene in the species Homo sapiens
| THSD1 |
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| Identifiers |
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| Aliases | THSD1, TMTSP, UNQ3010, thrombospondin type 1 domain containing 1, ANIB12 |
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| External IDs | OMIM: 616821; MGI: 1929096; HomoloGene: 10264; GeneCards: THSD1; OMA:THSD1 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 13 (human)[1] |
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| | Band | 13q14.3 | Start | 52,377,167 bp[1] |
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| End | 52,416,373 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 8 (mouse)[2] |
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| | Band | 8|8 A2 | Start | 22,717,329 bp[2] |
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| End | 22,751,350 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - ventricular zone
- right lung
- apex of heart
- placenta
- upper lobe of left lung
- testicle
- subcutaneous adipose tissue
- temporal lobe
- amygdala
- left ventricle
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| | Top expressed in | - external carotid artery
- internal carotid artery
- left lung lobe
- lip
- endothelial cell of lymphatic vessel
- skin of back
- right lung lobe
- hair follicle
- dermis
- yolk sac
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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NM_001205253
NM_001293688
NM_019576 |
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| RefSeq (protein) | | |
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NP_001192182
NP_001280617
NP_062522 |
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| Location (UCSC) | Chr 13: 52.38 – 52.42 Mb | Chr 8: 22.72 – 22.75 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Thrombospondin type-1 domain-containing protein 1 is a protein that in humans is encoded by the THSD1 gene.[5]
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in thrombospondin, a number of proteins involved in the complement pathway, as well as extracellular matrix proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136114 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031480 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: THSD1 thrombospondin, type I, domain containing 1".
Further reading
- Bork P (1993). "The modular architecture of a new family of growth regulators related to connective tissue growth factor". FEBS Lett. 327 (2): 125–30. doi:10.1016/0014-5793(93)80155-N. PMID 7687569.
- Gruber HE, Ingram JA, Hanley EN (2007). "Immunolocalization of thrombospondin in the human and sand rat intervertebral disc". Spine. 31 (22): 2556–61. doi:10.1097/01.brs.0000241117.31510.e3. PMID 17047544. S2CID 43521262.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE (2005). "Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly". J. Biol. Chem. 279 (47): 48983–92. doi:10.1074/jbc.M404881200. PMID 15371459.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
