TIMM44

Protein-coding gene in the species Homo sapiens
TIMM44
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CW9

Identifiers
AliasesTIMM44, TIM44, translocase of inner mitochondrial membrane 44
External IDsOMIM: 605058; MGI: 1343262; HomoloGene: 4631; GeneCards: TIMM44; OMA:TIMM44 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for TIMM44
Genomic location for TIMM44
Band19p13.2Start7,926,718 bp[1]
End7,943,667 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for TIMM44
Genomic location for TIMM44
Band8 A1.1|8 1.99 cMStart4,309,731 bp[2]
End4,325,913 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • gastrocnemius muscle

  • right hemisphere of cerebellum

  • muscle layer of sigmoid colon

  • body of uterus

  • left ventricle

  • right ovary

  • left ovary

  • canal of the cervix

  • gastric mucosa
Top expressed in
  • ciliary body

  • retinal pigment epithelium

  • right ventricle

  • neural layer of retina

  • sternocleidomastoid muscle

  • digastric muscle

  • temporal muscle

  • brown adipose tissue

  • internal carotid artery

  • iris
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • chaperone binding
  • protein binding
  • ATP binding
Cellular component
  • mitochondrial inner membrane
  • membrane
  • mitochondrion
  • mitochondrial matrix
Biological process
  • protein transport
  • protein targeting to mitochondrion
  • protein import into mitochondrial matrix
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10469

21856

Ensembl

ENSG00000104980

ENSMUSG00000002949

UniProt

O43615

O35857

RefSeq (mRNA)

NM_006351

NM_011592

RefSeq (protein)

NP_006342

NP_035722

Location (UCSC)Chr 19: 7.93 – 7.94 MbChr 8: 4.31 – 4.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.[5][6][7]


Interactions

TIMM44 has been shown to interact with ARAF.[5][8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104980 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002949 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (Jul 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol Cell Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
  6. ^ Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID 10339406.
  7. ^ "Entrez Gene: TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)".
  8. ^ Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2). United States: 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Moro F, Sirrenberg C, Schneider HC, et al. (1999). "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix". EMBO J. 18 (13): 3667–75. doi:10.1093/emboj/18.13.3667. PMC 1171444. PMID 10393182.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Mitochondrial import inner membrane translocase subunit TIM44


  • v
  • t
  • e
  • 2cw9: Crystal structure of human Tim44 C-terminal domain
    2cw9: Crystal structure of human Tim44 C-terminal domain


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