TMIGD2

Protein-coding gene in the species Homo sapiens

TMIGD2

Identifiers

Aliases

TMIGD2, IGPR-1, IGPR1, CD28H, transmembrane and immunoglobulin domain containing 2

External IDs

OMIM: 614715; HomoloGene: 89154; GeneCards: TMIGD2; OMA:TMIGD2 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.3	Start	4,292,227 bp^[1]
Band	19p13.3	End	4,302,431 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

myocardium of left ventricle

vena cava

buccal mucosa cell

cardiac muscle tissue of right atrium

cerebellar vermis

thymus

nasal epithelium

superficial temporal artery

cardia

Skeletal muscle tissue of rectus abdominis

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding coreceptor activity
Cellular component	integral component of membrane plasma membrane membrane extracellular space
Biological process	T cell costimulation immune response positive regulation of cytokine production immunoglobulin production positive regulation of activated T cell proliferation positive regulation of angiogenesis signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


126259


n/a

Ensembl


ENSG00000167664


n/a

UniProt


Q96BF3


n/a

RefSeq (mRNA)


NM_001169126 NM_001308232 NM_144615 NM_001395549


n/a

RefSeq (protein)


NP_001162597 NP_001295161 NP_653216


n/a

Location (UCSC)

Chr 19: 4.29 – 4.3 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Transmembrane and immunoglobulin domain containing 2 is a protein that in humans is encoded by the TMIGD2 gene.^[3]^[4]^[5]^[6] TMIGD2 was discovered by Nader Rahimi.^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167664 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Gene: TMIGD2". Ensembl Project.
^ "TMIG2_HUMAN". UniProt.
^ "TMIGD2". GeneCards.
^ "Cell Atlas: TMIGD2". The Human Protein Atlas.
^ Woolf N, Pearson BE, Bondzie PA, Meyer RD, Lavaei M, Belkina AC, et al. (September 2017). "Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy". Oncogenesis. 6 (9): e378. doi:10.1038/oncsis.2017.77. PMC 5623903. PMID 28920928.
^ Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, et al. (December 2016). "IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function". Journal of Molecular Biology. 428 (24 Pt B): 5019–5033. doi:10.1016/j.jmb.2016.11.003. PMC 5138093. PMID 27838321.
^ Rahimi N, Rezazadeh K, Mahoney JE, Hartsough E, Meyer RD (May 2012). "Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis". Molecular Biology of the Cell. 23 (9): 1646–56. doi:10.1091/mbc.E11-11-0934. PMC 3338432. PMID 22419821.