TNS1

Protein-coding gene in the species Homo sapiens
TNS1
Identifiers
AliasesTNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDsOMIM: 600076; MGI: 104552; HomoloGene: 11219; GeneCards: TNS1; OMA:TNS1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for TNS1
Genomic location for TNS1
Band2q35Start217,799,789 bp[1]
End218,002,995 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for TNS1
Genomic location for TNS1
Band1 C3|1 38.17 cMStart73,949,390 bp[2]
End74,163,608 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • saphenous vein

  • urethra

  • tail of epididymis

  • lower lobe of lung

  • seminal vesicula

  • myocardium of left ventricle

  • cardiac muscle tissue of right atrium

  • right coronary artery

  • popliteal artery

  • tibial arteries
Top expressed in
  • ascending aorta

  • aortic valve

  • interventricular septum

  • right lung

  • left lung

  • right lung lobe

  • left lung lobe

  • muscle of thigh

  • tunica media of zone of aorta

  • myocardium of ventricle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • actin binding
  • protein binding
  • RNA binding
Cellular component
  • cytoplasm
  • cell-substrate junction
  • cell surface
  • cell junction
  • cytoskeleton
  • focal adhesion
Biological process
  • cell-substrate junction assembly
  • fibroblast migration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7145

21961

Ensembl

ENSG00000079308

ENSMUSG00000055322

UniProt

Q9HBL0
Q0VG54

n/a

RefSeq (mRNA)

NM_001308022
NM_001308023
NM_022648

NM_001289895
NM_027884
NM_177169

RefSeq (protein)

NP_001294951
NP_001294952
NP_072174
NP_001294951.1
NP_001294952.1

n/a

Location (UCSC)Chr 2: 217.8 – 218 MbChr 1: 73.95 – 74.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.[5]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079308 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055322 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TNS1 tensin 1".

Further reading

  • Jankowski SA, Gumucio DL (1996). "Genes for tensin, villin and desmin are linked on mouse chromosome 1" (PDF). Mamm. Genome. 6 (10): 744–5. doi:10.1007/BF00354299. hdl:2027.42/47016. PMID 8563175. S2CID 22316923.
  • Salgia R, Pisick E, Sattler M, et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J. Biol. Chem. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Katz BZ, Zohar M, Teramoto H, et al. (2000). "Tensin can induce JNK and p38 activation". Biochem. Biophys. Res. Commun. 272 (3): 717–20. doi:10.1006/bbrc.2000.2853. PMID 10860821.
  • Chen H, Ishii A, Wong WK, et al. (2001). "Molecular characterization of human tensin". Biochem. J. 351 Pt 2 (2): 403–11. doi:10.1042/0264-6021:3510403. PMC 1221376. PMID 11023826.
  • Benzing T, Gerke P, Höpker K, et al. (2001). "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9784–9. Bibcode:2001PNAS...98.9784B. doi:10.1073/pnas.171269898. PMC 55530. PMID 11493697.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yamashita M, Horikoshi S, Asanuma K, et al. (2004). "Tensin is potentially involved in extracellular matrix production in mesangial cells". Histochem. Cell Biol. 121 (3): 245–54. doi:10.1007/s00418-004-0626-8. PMID 14991332. S2CID 5634607.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Eto M, Kirkbride J, Elliott E, et al. (2007). "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions". J. Biol. Chem. 282 (24): 17806–15. doi:10.1074/jbc.M700944200. PMID 17435217.


  • v
  • t
  • e