TRIM16

Gene of the species Homo sapiens
TRIM16
Identifiers
AliasesTRIM16, EBBP, tripartite motif containing 16
External IDsOMIM: 609505; MGI: 2137356; HomoloGene: 4726; GeneCards: TRIM16; OMA:TRIM16 - orthologs
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[1]
Chromosome 11 (mouse)
Genomic location for TRIM16
Genomic location for TRIM16
Band11|11 B2Start62,711,057 bp[1]
End62,741,634 bp[1]
Gene ontology
Molecular function
  • DNA binding
  • zinc ion binding
  • interleukin-1 binding
  • protein binding
  • metal ion binding
  • NACHT domain binding
  • transferase activity
Cellular component
  • cytoplasm
  • PML body
  • intracellular anatomical structure
  • cytosol
  • plasma membrane
Biological process
  • histone H4 acetylation
  • positive regulation of keratinocyte differentiation
  • positive regulation of transcription, DNA-templated
  • response to organophosphorus
  • positive regulation of retinoic acid receptor signaling pathway
  • response to retinoic acid
  • histone H3 acetylation
  • response to growth hormone
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10626

94092

Ensembl

ENSG00000221926

ENSMUSG00000047821

UniProt

O95361

Q99PP9

RefSeq (mRNA)

NM_006470

NM_053169

RefSeq (protein)
NP_006461
NP_001335049
NP_001335050
NP_001335051
NP_001335053

NP_001335054
NP_001335055
NP_001335048

NP_444399

Location (UCSC)n/aChr 11: 62.71 – 62.74 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.[4][5]

This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family.

The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.[5]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047821 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  5. ^ a b "Entrez Gene: TRIM16 tripartite motif-containing 16".

Further reading

  • Liu HL, Golder-Novoselsky E, Seto MH, et al. (1999). "The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant". Mol. Endocrinol. 12 (11): 1733–48. doi:10.1210/mend.12.11.0193. PMID 9817599.
  • Beer HD, Munding C, Dubois N, et al. (2002). "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation". J. Biol. Chem. 277 (23): 20740–9. doi:10.1074/jbc.M111233200. hdl:20.500.11850/91604. PMID 11919186.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Munding C, Keller M, Niklaus G, et al. (2006). "The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion". Cell Death Differ. 13 (11): 1938–49. doi:10.1038/sj.cdd.4401896. PMID 16575408. S2CID 8953820.
  • Cheung BB, Bell J, Raif A, et al. (2006). "The estrogen-responsive B box protein is a novel regulator of the retinoid signal". J. Biol. Chem. 281 (26): 18246–56. doi:10.1074/jbc.M600879200. PMID 16636064.


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