Transcription termination factor, RNA polymerase I

Protein-coding gene in the species Homo sapiens
TTF1
Identifiers
AliasesTTF1, TTF-1, TTF-I, Transcription termination factor, RNA polymerase I, transcription termination factor 1
External IDsOMIM: 600777; MGI: 105044; HomoloGene: 135863; GeneCards: TTF1; OMA:TTF1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for TTF1
Genomic location for TTF1
Band9q34.13Start132,375,548 bp[1]
End132,406,851 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for TTF1
Genomic location for TTF1
Band2|2 A3Start28,950,274 bp[2]
End28,977,668 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • trabecular bone

  • oocyte

  • secondary oocyte

  • pylorus

  • pericardium

  • cardia

  • nipple

  • superior surface of tongue

  • vena cava
Top expressed in
  • gastrula

  • neural layer of retina

  • submandibular gland

  • spermatocyte

  • granulocyte

  • Paneth cell

  • thymus

  • ventricular zone

  • morula

  • morula
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • sequence-specific DNA binding
  • chromatin binding
Cellular component
  • plasma membrane
  • nucleolus
  • nucleoplasm
  • cytosol
  • nucleus
Biological process
  • DNA-templated transcription, termination
  • negative regulation of DNA replication
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • cell differentiation
  • termination of RNA polymerase I transcription
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7270

22130

Ensembl

ENSG00000125482

ENSMUSG00000026803

UniProt

Q15361

Q62187

RefSeq (mRNA)

NM_001205296
NM_007344

NM_009442

RefSeq (protein)

NP_001192225
NP_031370

NP_033468

Location (UCSC)Chr 9: 132.38 – 132.41 MbChr 2: 28.95 – 28.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription termination factor 1 is a protein that in humans is encoded by the TTF1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125482 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026803 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Evers R, Grummt I (Aug 1995). "Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I". Proc Natl Acad Sci U S A. 92 (13): 5827–31. Bibcode:1995PNAS...92.5827E. doi:10.1073/pnas.92.13.5827. PMC 41594. PMID 7597036.
  6. ^ "Entrez Gene: TTF1 transcription termination factor, RNA polymerase I".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I (1998). "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". EMBO J. 17 (10): 2855–64. doi:10.1093/emboj/17.10.2855. PMC 1170626. PMID 9582279.
  • Muth V, Nadaud S, Grummt I, Voit R (2001). "Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription". EMBO J. 20 (6): 1353–62. doi:10.1093/emboj/20.6.1353. PMC 145524. PMID 11250901.
  • Strohner R, Nemeth A, Jansa P, et al. (2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". EMBO J. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Takano T, Ito Y, Matsuzuka F, et al. (2007). "Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines". Oncol. Rep. 18 (3): 715–20. doi:10.3892/or.18.3.715. PMID 17671725.


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