UNC5A

Protein-coding gene in the species Homo sapiens
UNC5A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4V2A

Identifiers
AliasesUNC5A, UNC5H1, unc-5 netrin receptor A
External IDsOMIM: 607869; MGI: 894682; HomoloGene: 41474; GeneCards: UNC5A; OMA:UNC5A - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for UNC5A
Genomic location for UNC5A
Band5q35.2Start176,810,519 bp[1]
End176,880,898 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for UNC5A
Genomic location for UNC5A
Band13|13 B1Start55,097,224 bp[2]
End55,153,831 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • middle temporal gyrus

  • Brodmann area 23

  • primary visual cortex

  • right hemisphere of cerebellum

  • right frontal lobe

  • prefrontal cortex

  • superior frontal gyrus

  • Brodmann area 9

  • postcentral gyrus
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • secondary oocyte

  • superior frontal gyrus

  • lumbar subsegment of spinal cord

  • hippocampus proper

  • humerus

  • transitional epithelium of urinary bladder

  • primary oocyte

  • neural layer of retina
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • netrin receptor activity
Cellular component
  • intrinsic component of plasma membrane
  • integral component of membrane
  • neuronal cell body membrane
  • membrane raft
  • plasma membrane
  • cell projection
  • neuron projection membrane
  • membrane
Biological process
  • multicellular organism development
  • neuron projection development
  • signal transduction
  • anterior/posterior axon guidance
  • axon guidance
  • apoptotic process
  • netrin-activated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

90249

107448

Ensembl

ENSG00000113763

ENSMUSG00000025876

UniProt

Q6ZN44

Q8K1S4

RefSeq (mRNA)

NM_133369

NM_153131
NM_001311128

RefSeq (protein)

NP_588610

NP_001298057
NP_694771

Location (UCSC)Chr 5: 176.81 – 176.88 MbChr 13: 55.1 – 55.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.[5]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM][5]

Interactions

UNC5A has been shown to interact with MAGED1.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113763 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025876 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
  6. ^ Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.

Further reading

  • Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer. 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119. S2CID 867903.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  • Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
  • Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906. S2CID 7017409.
  • Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
  • Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". The Journal of Biological Chemistry. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
  • Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". The EMBO Journal. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.


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