Uroguanylin
guanylate cyclase activator 2B (uroguanylin) | |||||||
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Identifiers | |||||||
Symbol | GUCA2B | ||||||
NCBI gene | 2981 | ||||||
HGNC | 4683 | ||||||
OMIM | 601271 | ||||||
RefSeq | NM_007102 | ||||||
UniProt | Q16661 | ||||||
Other data | |||||||
Locus | Chr. 1 p34-p33 | ||||||
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3D model (JSmol) |
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ChemSpider |
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MeSH | uroguanylin |
PubChem CID |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |
Chemical formula | C61H101N17O25S4 |
Molar mass | 1600.81 g·mol−1 |
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Related compounds | PMDTA |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. By agonizing this guanylyl cyclase receptor, uroguanylin and guanylin cause intestinal secretion of chloride and bicarbonate to dramatically increase; this process is helped by the second messenger cGMP.[1] Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.
In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[2][3] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[4]
See also
- Natriuretic peptide
- Plecanatide – a medication structurally related to uroguanylin
References
- ^ Forte, Leonard Ralph (1 November 2004). "Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics". Pharmacology & Therapeutics. 104 (2): 137–162. doi:10.1016/j.pharmthera.2004.08.007. PMID 15518884. Retrieved 16 January 2023.
- ^ Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S (February 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.
- ^ Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (August 1997). "Genomic structure and chromosomal localization of human uroguanylin". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.
- ^ Rahbi H, Narayan H, Jones DJ, Ng LL (December 2012). "The uroguanylin system and human disease". Clinical Science. 123 (12): 659–68. doi:10.1042/CS20120021. PMID 22877138. S2CID 16444915.
External links
- uroguanylin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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